OBJECTIVES: It has been shown that the HCV-core protein reduces the activity of microsomal triglyceride transfer protein (MTP) and could lead to steatosis in HCV-infected patients. The aim of our study was to investigate the influence of a functional polymorphism in the promoter region of the MTP gene (493G/T) on the development of HCV-related steatosis. METHODS: Eighty-six chronic hepatitis C patients were studied to assess: the effects of body mass index, age, HCV genotype, and 493G/T MTP polymorphism on steatosis. RESULTS: Steatosis was observed in 39 patients (45.3%). The 493G/T MTP polymorphism were not related to the development of steatosis. CONCLUSION: The functional G/T MTP polymorphism do not seem to play any role in the development of steatosis in chronic hepatitis C.
OBJECTIVES: It has been shown that the HCV-core protein reduces the activity of microsomal triglyceride transfer protein (MTP) and could lead to steatosis in HCV-infectedpatients. The aim of our study was to investigate the influence of a functional polymorphism in the promoter region of the MTP gene (493G/T) on the development of HCV-related steatosis. METHODS: Eighty-six chronic hepatitis Cpatients were studied to assess: the effects of body mass index, age, HCV genotype, and 493G/TMTP polymorphism on steatosis. RESULTS:Steatosis was observed in 39 patients (45.3%). The 493G/TMTP polymorphism were not related to the development of steatosis. CONCLUSION: The functional G/T MTP polymorphism do not seem to play any role in the development of steatosis in chronic hepatitis C.
Authors: E R F Siqueira; C P M S Oliveira; M L Correa-Giannella; J T Stefano; A M Cavaleiro; M A H Z Fortes; M T C Muniz; F S Silva; L M M B Pereira; F J Carrilho Journal: Braz J Med Biol Res Date: 2011-12-09 Impact factor: 2.590