| Literature DB >> 16457895 |
Lenin Pavón1, Gabriel Sandoval-López, María Eugenia Hernández, Frida Loría, Iris Estrada, Mayra Pérez, Julia Moreno, Ulises Avila, Philippe Leff, Benito Antón, Gerhard Heinze.
Abstract
In Major Depressive Disorder (MDD), the neuroendocrine and immune systems interactions are impaired. We investigated the pro/anti-inflammatory Th1/Th2 cytokine balance in MDD patients and in non-depressed control group. The MDD subjects showed higher levels of cortisol and TNF-alpha, increased CD3+CD8+ and NK percentages, diminished B cell counts and no significant variations in CD3+CD4+ lymphocyte. Moreover, higher levels of IL-4 and IL-13 (Th2) and significantly lower measurements of IL-2 and IFN-gamma (Th1) cytokines were also observed in the MDD group. Overall, we propose that all these changes could be related to the elevated cortisol levels seen in the MDD patients. Further studies are necessary to explore these findings and its implication in future therapeutic approach of MDD patients.Entities:
Mesh：
Substances：
Year: 2006 PMID： 16457895 DOI： 10.1016/j.jneuroim.2005.08.014
Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478