| Literature DB >> 16456711 |
Li Ma1, Xiangshan Zhao, Xueliang Zhu.
Abstract
Mitosin/CENP-F is a large nuclear/kinetochore protein containing multiple leucine zipper motifs potentially for protein interactions. Its expression levels and subcellular localization patterns are regulated in a cell cycle-dependent manner. Recently, accumulating lines of evidence have suggested it a multifunctional protein involved in mitotic control, microtubule dynamics, transcriptional regulation, and muscle cell differentiation. Consistently, it is shown to interact directly with a variety of proteins including CENP-E, NudE/Nudel, ATF4, and Rb. Here we review the current progress and discuss possible mechanisms through which mitosin may function.Entities:
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Year: 2006 PMID： 16456711 DOI： 10.1007/s11373-005-9057-3
Source DB: PubMed Journal: J Biomed Sci ISSN： 1021-7770 Impact factor: 8.410