Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Regulation of mucin genes in chronic inflammatory airway diseases.

Literature DB >> 16456183

Regulation of mucin genes in chronic inflammatory airway diseases.

Judith A Voynow¹, Sandra J Gendler, Mary C Rose.

Abstract

In this review, we summarize work over the past 15 years on mucin gene expression and regulation in the lung, as well as how mucin gene expression is altered in chronic lung diseases. This field owes a great debt to Carol Basbaum for her pioneering work in dissecting signaling pathways regulating mucin gene expression and for her tremendous energy in promoting the importance of understanding the basic pathogenic mechanisms that drive mucus overproduction in cystic fibrosis, chronic obstructive pulmonary disease, and asthma.

Entities: Disease Gene

Mesh：

Substances：

Year: 2006 PMID： 16456183 DOI： 10.1165/rcmb.2006-0035SF

Source DB: PubMed Journal: Am J Respir Cell Mol Biol ISSN： 1044-1549 Impact factor: 6.914

Keyword Cloud
Cited

77 in total

1. Characterizing the impact of smoking and lung cancer on the airway transcriptome using RNA-Seq.

Authors: Jennifer Beane; Jessica Vick; Frank Schembri; Christina Anderlind; Adam Gower; Joshua Campbell; Lingqi Luo; Xiao Hui Zhang; Ji Xiao; Yuriy O Alekseyev; Shenglong Wang; Shawn Levy; Pierre P Massion; Marc Lenburg; Avrum Spira
Journal: Cancer Prev Res (Phila) Date: 2011-06

2. 2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced MUC5AC expression: aryl hydrocarbon receptor-independent/EGFR/ERK/p38-dependent SP1-based transcription.

Authors: Yong C Lee; Karen L Oslund; Philip Thai; Sharlene Velichko; Tomoyuki Fujisawa; Trang Duong; Michael S Denison; Reen Wu
Journal: Am J Respir Cell Mol Biol Date: 2010-10-22 Impact factor: 6.914

3. Molecular cloning of two novel mucin-like genes in the disease-susceptibility locus for diffuse panbronchiolitis.

Authors: Minako Hijikata; Ikumi Matsushita; Goh Tanaka; Tomoko Tsuchiya; Hideyuki Ito; Katsushi Tokunaga; Jun Ohashi; Sakae Homma; Yoichiro Kobashi; Yoshio Taguchi; Arata Azuma; Shoji Kudoh; Naoto Keicho
Journal: Hum Genet Date: 2010-10-28 Impact factor: 4.132

4. The extracellular signal-regulated kinase mitogen-activated protein kinase/ribosomal S6 protein kinase 1 cascade phosphorylates cAMP response element-binding protein to induce MUC5B gene expression via D-prostanoid receptor signaling.

Authors: Yeon Ho Choi; Sang-Nam Lee; Hiroki Aoyagi; Yasundo Yamasaki; Jung-Yoon Yoo; Boryung Park; Dong Min Shin; Ho-Geun Yoon; Joo-Heon Yoon
Journal: J Biol Chem Date: 2011-08-10 Impact factor: 5.157

Regulation of mucin genes in chronic inflammatory airway diseases.

1. Characterizing the impact of smoking and lung cancer on the airway transcriptome using RNA-Seq.

2. 2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced MUC5AC expression: aryl hydrocarbon receptor-independent/EGFR/ERK/p38-dependent SP1-based transcription.

3. Molecular cloning of two novel mucin-like genes in the disease-susceptibility locus for diffuse panbronchiolitis.

4. The extracellular signal-regulated kinase mitogen-activated protein kinase/ribosomal S6 protein kinase 1 cascade phosphorylates cAMP response element-binding protein to induce MUC5B gene expression via D-prostanoid receptor signaling.

5. Functional analysis of human MUC7 mucin gene 5'-flanking region in lung epithelial cells.

6. Vanadium pentoxide (V(2)O(5)) induced mucin production by airway epithelium.

Review 7. The airway epithelium: soldier in the fight against respiratory viruses.

8. Airway epithelial homeostasis and planar cell polarity signaling depend on multiciliated cell differentiation.

9. Effect of budesonide and azelastine on histamine signaling regulation in human nasal epithelial cells.

10. Smoking-mediated up-regulation of GAD67 expression in the human airway epithelium.