RATIONALE: Bronchial thermoplasty (BT) reduces the potential for smooth muscle-mediated bronchoconstriction by reducing the mass of smooth muscle in the walls of conducting airways. OBJECTIVES: This study was conducted to examine the safety and impact on lung function and airway responsiveness of BT over 2 yr. METHODS: The safety of BT was studied in 16 subjects with mild to moderate asthma. Baseline and 12-wk post-treatment measurements included spirometry, methacholine challenge, daily diary recordings of peak flow, symptoms, and medication usage. Subjects completed follow-up evaluations at 12 wk, 1 yr, and 2 yr. MEASUREMENTS AND MAIN RESULTS: The procedure was well tolerated; side effects were transient and typical of what is commonly observed after bronchoscopy. All subjects demonstrated improvement in airway responsiveness. The mean PC(20) increased by 2.37 +/- 1.72 (p < 0.001), 2.77 +/- 1.53 (p = 0.007), and 2.64 +/- 1.52 doublings (p < 0.001), at 12 wk, 1 yr, and 2 yr post-procedure, respectively. Data from daily diaries collected for 12 wk indicated significant improvements over baseline in symptom-free days (p = 0.015), morning peak flow (p = 0.01), and evening peak flow (p < or = 0.007). Spirometry measurements remained stable throughout the study period. CONCLUSIONS: BT is well tolerated in patients with asthma and results in decreased airway hyperresponsiveness that persists for at least 2 yr.
RATIONALE: Bronchial thermoplasty (BT) reduces the potential for smooth muscle-mediated bronchoconstriction by reducing the mass of smooth muscle in the walls of conducting airways. OBJECTIVES: This study was conducted to examine the safety and impact on lung function and airway responsiveness of BT over 2 yr. METHODS: The safety of BT was studied in 16 subjects with mild to moderate asthma. Baseline and 12-wk post-treatment measurements included spirometry, methacholine challenge, daily diary recordings of peak flow, symptoms, and medication usage. Subjects completed follow-up evaluations at 12 wk, 1 yr, and 2 yr. MEASUREMENTS AND MAIN RESULTS: The procedure was well tolerated; side effects were transient and typical of what is commonly observed after bronchoscopy. All subjects demonstrated improvement in airway responsiveness. The mean PC(20) increased by 2.37 +/- 1.72 (p < 0.001), 2.77 +/- 1.53 (p = 0.007), and 2.64 +/- 1.52 doublings (p < 0.001), at 12 wk, 1 yr, and 2 yr post-procedure, respectively. Data from daily diaries collected for 12 wk indicated significant improvements over baseline in symptom-free days (p = 0.015), morning peak flow (p = 0.01), and evening peak flow (p < or = 0.007). Spirometry measurements remained stable throughout the study period. CONCLUSIONS: BT is well tolerated in patients with asthma and results in decreased airway hyperresponsiveness that persists for at least 2 yr.
Authors: Pasquale Chitano; Lu Wang; Stanley N Mason; Richard L Auten; Erin N Potts; William M Foster; Anne Sturrock; Thomas P Kennedy; John R Hoidal; Thomas M Murphy Journal: Am J Physiol Lung Cell Mol Physiol Date: 2007-11-09 Impact factor: 5.464
Authors: S S An; T R Bai; J H T Bates; J L Black; R H Brown; V Brusasco; P Chitano; L Deng; M Dowell; D H Eidelman; B Fabry; N J Fairbank; L E Ford; J J Fredberg; W T Gerthoffer; S H Gilbert; R Gosens; S J Gunst; A J Halayko; R H Ingram; C G Irvin; A L James; L J Janssen; G G King; D A Knight; A M Lauzon; O J Lakser; M S Ludwig; K R Lutchen; G N Maksym; J G Martin; T Mauad; B E McParland; S M Mijailovich; H W Mitchell; R W Mitchell; W Mitzner; T M Murphy; P D Paré; R Pellegrino; M J Sanderson; R R Schellenberg; C Y Seow; P S P Silveira; P G Smith; J Solway; N L Stephens; P J Sterk; A G Stewart; D D Tang; R S Tepper; T Tran; L Wang Journal: Eur Respir J Date: 2007-05 Impact factor: 16.671
Authors: Diana C Doeing; Amit K Mahajan; Steven R White; Edward T Naureckas; Jerry A Krishnan; Douglas K Hogarth Journal: J Asthma Date: 2012-12-20 Impact factor: 2.515