Literature DB >> 16455610

Enhancing the bioavailability of cyclosporine a using solid dispersion containing polyoxyethylene (40) stearate.

Chen Liu1, Junhua Wu, Bin Shi, Yuanxing Zhang, Tiankun Gao, Yuanying Pei.   

Abstract

Solid dispersion containing polyoxyethylene (40) stearate and cyclosporine A was prepared by solvent-melt method and characterized using differential scanning calorimetry, powder X-ray diffraction, and Infrared Fourier Transform Spectroscopy (FTIR). Dissolution of the drug from solid dispersion was dramatically enhanced compared to that from the drug powder alone and physical mixture. In vivo oral bioavailability of cyclosporine A from the solid dispersion in Wistar rats was comparable to that from a commercial product, Sandimmun Neoral (P>0.05). The formulation is stable up to six months under 30 degrees C/RH60% and one year at 25 degrees C/RH 60% when packed in aluminum-polyethylene laminated bags.

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Year:  2006        PMID： 16455610     DOI： 10.1080/03639040500388573

Source DB:  PubMed          Journal:  Drug Dev Ind Pharm        ISSN： 0363-9045            Impact factor:   3.225


  10 in total

1.  Development and Characterization of PEGylated Fatty Acid-Block-Poly(ε-caprolactone) Novel Block Copolymers and Their Self-Assembled Nanostructures for Ocular Delivery of Cyclosporine A.

Authors:  Ziyad Binkhathlan; Abdullah H Alomrani; Olsi Hoxha; Raisuddin Ali; Mohd Abul Kalam; Aws Alshamsan
Journal:  Polymers (Basel)       Date:  2022-04-19       Impact factor: 4.967

2.  Polyoxyethylene 40 stearate modulates multidrug resistance and enhances antitumor activity of vinblastine sulfate.

Authors:  Lingying Luo; Xiaoqiang Xu; Beijia Shi; Jinhui Wu; Yiqiao Hu
Journal:  AAPS J       Date:  2007-10-05       Impact factor: 4.009

3.  Characterization of a cyclosporine solid dispersion for inhalation.

Authors:  Gerrit S Zijlstra; Michiel Rijkeboer; Dirk Jan van Drooge; Marc Sutter; Wim Jiskoot; Marco van de Weert; Wouter L J Hinrichs; Henderik W Frijlink
Journal:  AAPS J       Date:  2007-06-15       Impact factor: 4.009

4.  Enhanced oral bioavailability of cyclosporine A by liposomes containing a bile salt.

Authors:  Peipei Guan; Yi Lu; Jianping Qi; Mengmeng Niu; Ruyue Lian; Fuqiang Hu; Wei Wu
Journal:  Int J Nanomedicine       Date:  2011-05-04

5.  Enhancement of oral bioavailability of cyclosporine A: comparison of various nanoscale drug-delivery systems.

Authors:  Kai Wang; Jianping Qi; Tengfei Weng; Zhiqiang Tian; Yi Lu; Kaili Hu; Zongning Yin; Wei Wu
Journal:  Int J Nanomedicine       Date:  2014-10-28

6.  The Effect of Surfactant Type and Concentration on Physicochemical Properties of Carvedilol Solid Dispersions Prepared by Wet Milling Method.

Authors:  Noushin Bolourchian; Mina Shafiee Panah
Journal:  Iran J Pharm Res       Date:  2022-05-09       Impact factor: 1.962

7.  Pharmacokinetics and enhanced oral bioavailability in beagle dogs of cyclosporine A encapsulated in glyceryl monooleate/poloxamer 407 cubic nanoparticles.

Authors:  Jie Lai; Yi Lu; Zongning Yin; Fuqiang Hu; Wei Wu
Journal:  Int J Nanomedicine       Date:  2010-02-02

Review 8.  Natural and synthetic polymers as inhibitors of drug efflux pumps.

Authors:  Martin Werle
Journal:  Pharm Res       Date:  2007-09-26       Impact factor: 4.200

9.  Overcoming the cutaneous barrier with microemulsions.

Authors:  Luciana B Lopes
Journal:  Pharmaceutics       Date:  2014-02-28       Impact factor: 6.321

Review 10.  Oral cyclosporine A--the current picture of its liposomal and other delivery systems.

Authors:  Aleksander Czogalla
Journal:  Cell Mol Biol Lett       Date:  2008-11-12       Impact factor: 5.787
  10 in total

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