OBJECTIVE: We sought to study the relative effect on left ventricular (LV) and right ventricular (RV) function of low-dose anthracycline-containing chemotherapy regimes. METHODS: A total of 23 patients (mean age 48 +/- 20 years) underwent echocardiographic examinations before any anthracycline had been administered and then after low-dose anthracycline (doxorubicin 50-125 mg/m2). The Tei index was used to compare the relative effects on RV and LV function. RESULTS: Anthracycline administration was significantly associated with an increase in the LV Tei index (0.38 +/- 0.12 vs 0.46 +/- 0.16, P = .02). There was no significant change in the RV Tei index (0.19 +/- 0.10 vs 0.20 +/- 0.10, P = .72). Comparing the relative effect on global LV and RV function the change in LV Tei was significantly greater than the change in RV Tei (0.07 +/- 0.13 vs 0.01 +/- 0.09, P = .044). CONCLUSIONS: Low-dose anthracycline administration has a significant negative impact on LV function but does not affect RV function.
OBJECTIVE: We sought to study the relative effect on left ventricular (LV) and right ventricular (RV) function of low-dose anthracycline-containing chemotherapy regimes. METHODS: A total of 23 patients (mean age 48 +/- 20 years) underwent echocardiographic examinations before any anthracycline had been administered and then after low-dose anthracycline (doxorubicin 50-125 mg/m2). The Tei index was used to compare the relative effects on RV and LV function. RESULTS:Anthracycline administration was significantly associated with an increase in the LV Tei index (0.38 +/- 0.12 vs 0.46 +/- 0.16, P = .02). There was no significant change in the RV Tei index (0.19 +/- 0.10 vs 0.20 +/- 0.10, P = .72). Comparing the relative effect on global LV and RV function the change in LV Tei was significantly greater than the change in RV Tei (0.07 +/- 0.13 vs 0.01 +/- 0.09, P = .044). CONCLUSIONS: Low-dose anthracycline administration has a significant negative impact on LV function but does not affect RV function.
Authors: Kevin Emery Boczar; Olexiy Aseyev; Jeffrey Sulpher; Christopher Johnson; Ian G Burwash; Michele Turek; Susan Dent; Girish Dwivedi Journal: Echo Res Pract Date: 2016-07-25