Literature DB >> 16455250

Synthesis of carbon-11 and fluorine-18 labeled N-acetyl-1-aryl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline derivatives as new potential PET AMPA receptor ligands.

Mingzhang Gao1, Deyuan Kong, Abraham Clearfield, Qi-Huang Zheng.   

Abstract

New carbon-11 and fluorine-18 labeled N-acetyl-1-aryl-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline derivatives were designed and synthesized as potential positron emission tomography AMPA (2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid) receptor ligands to image brain diseases. The single crystal structure of the most potent compound N-acetyl-1-(4'-chlorophenyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline (5a) is first reported.

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Year:  2006        PMID： 16455250     DOI： 10.1016/j.bmcl.2006.01.042

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  8 in total

1.  Synthesis and evaluation of 6-(11C-methyl(4-(pyridin-2-yl)thiazol-2-yl)amino)benzo[d]thiazol-2(3H)-one for imaging γ-8 dependent transmembrane AMPA receptor regulatory protein by PET.

Authors:  Qingzhen Yu; Katsushi Kumata; Hua Li; Yiding Zhang; Zhen Chen; Xiaofei Zhang; Tuo Shao; Akiko Hatori; Tomoteru Yamasaki; Lin Xie; Kuan Hu; Gangqiang Wang; Lee Josephson; Shaofa Sun; Ming-Rong Zhang; Steven H Liang
Journal:  Bioorg Med Chem Lett       Date:  2019-12-17       Impact factor: 2.823

Review 2.  Positron Emission Tomography (PET) Ligand Development for Ionotropic Glutamate Receptors: Challenges and Opportunities for Radiotracer Targeting N-Methyl-d-aspartate (NMDA), α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA), and Kainate Receptors.

Authors:  Hualong Fu; Zhen Chen; Lee Josephson; Zijing Li; Steven H Liang
Journal:  J Med Chem       Date:  2018-08-27       Impact factor: 7.446

3.  Synthesis, pharmacology and preclinical evaluation of 11C-labeled 1,3-dihydro-2H-benzo[d]imidazole-2-ones for imaging γ8-dependent transmembrane AMPA receptor regulatory protein.

Authors:  Zhen Chen; Wakana Mori; Xiaofei Zhang; Tomoteru Yamasaki; Patrick J Dunn; Genwei Zhang; Hualong Fu; Tuo Shao; Yiding Zhang; Akiko Hatori; Longle Ma; Masayuki Fujinaga; Lin Xie; Xiaoyun Deng; Hua Li; Qingzhen Yu; Jian Rong; Lee Josephson; Jun-An Ma; Yihan Shao; Susumu Tomita; Ming-Rong Zhang; Steven H Liang
Journal:  Eur J Med Chem       Date:  2018-08-09       Impact factor: 6.514

4.  Radiosynthesis and preliminary evaluation of 11C-labeled 4-cyclopropyl-7-(3-methoxyphenoxy)-3,4-dihydro-2H-benzo[e] [1,2,4] thiadiazine 1,1-dioxide for PET imaging AMPA receptors.

Authors:  Jiahui Chen; Jiefeng Gan; Jiyun Sun; Zhen Chen; Hualong Fu; Jian Rong; Xiaoyun Deng; Jingjie Shang; Jian Gong; Tuo Shao; Lee Collier; Lu Wang; Hao Xu; Steven H Liang
Journal:  Tetrahedron Lett       Date:  2020-01-17       Impact factor: 2.415

5.  Radiosynthesis and preliminary PET evaluation of (18)F-labeled 2-(1-(3-fluorophenyl)-2-oxo-5-(pyrimidin-2-yl)-1,2-dihydropyridin-3-yl)benzonitrile for imaging AMPA receptors.

Authors:  Gengyang Yuan; Graham B Jones; Neil Vasdev; Steven H Liang
Journal:  Bioorg Med Chem Lett       Date:  2016-08-09       Impact factor: 2.823

6.  Direct functionalization of (un)protected tetrahydroisoquinoline and isochroman under iron and copper catalysis: two metals, two mechanisms.

Authors:  Michael Ghobrial; Michael Schnürch; Marko D Mihovilovic
Journal:  J Org Chem       Date:  2011-10-05       Impact factor: 4.354

7.  Translational medicine of the glutamate AMPA receptor.

Authors:  Tomoyuki Miyazaki; Hiroki Abe; Hiroyuki Uchida; Takuya Takahashi
Journal:  Proc Jpn Acad Ser B Phys Biol Sci       Date:  2021       Impact factor: 3.493

Review 8.  A Review of Molecular Imaging of Glutamate Receptors.

Authors:  Jong-Hoon Kim; János Marton; Simon Mensah Ametamey; Paul Cumming
Journal:  Molecules       Date:  2020-10-16       Impact factor: 4.411
  8 in total

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