Literature DB >> 16455242

Semisynthesis of C-ring modified triptolide analogues and their cytotoxic activities.

Yutaka Aoyagi1, Yukio Hitotsuyanagi, Tomoyo Hasuda, Haruhiko Fukaya, Koichi Takeya, Ritsuo Aiyama, Takeshi Matsuzaki, Shusuke Hashimoto.   

Abstract

Several C-ring modified analogues of a potent antileukemic diterpene, triptolide (1), were synthesized and their structure-activity relationships were studied.

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Year:  2006        PMID： 16455242     DOI： 10.1016/j.bmcl.2005.12.098

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  4 in total

1.  XPB, a subunit of TFIIH, is a target of the natural product triptolide.

Authors:  Denis V Titov; Benjamin Gilman; Qing-Li He; Shridhar Bhat; Woon-Kai Low; Yongjun Dang; Michael Smeaton; Arnold L Demain; Paul S Miller; Jennifer F Kugel; James A Goodrich; Jun O Liu
Journal:  Nat Chem Biol       Date:  2011-01-30       Impact factor: 15.040

2.  PTEN-induced partial epithelial-mesenchymal transition drives diabetic kidney disease.

Authors:  Yajuan Li; Qingsong Hu; Chunlai Li; Ke Liang; Yu Xiang; Heidi Hsiao; Tina K Nguyen; Peter K Park; Sergey D Egranov; Chandrashekar R Ambati; Nagireddy Putluri; David H Hawke; Leng Han; Mien-Chie Hung; Farhad R Danesh; Liuqing Yang; Chunru Lin
Journal:  J Clin Invest       Date:  2019-02-11       Impact factor: 14.808

3.  Dynamic kinetic resolution during a vinylogous Payne rearrangement: a concise synthesis of the polar pharmacophoric subunit of (+)-scyphostatin.

Authors:  Thomas R Hoye; Christopher S Jeffrey; Dorian P Nelson
Journal:  Org Lett       Date:  2010-01-01       Impact factor: 6.005

Review 4.  A review of the total syntheses of triptolide.

Authors:  Xiang Zhang; Zaozao Xiao; Hongtao Xu
Journal:  Beilstein J Org Chem       Date:  2019-08-22       Impact factor: 2.883
  4 in total

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