[Correlation of age, IGF-1 serum levels, muscular mass index and their influence as determinants of isokinetic variables in patients with osteoporosis].

INTRODUCTION: Bone and skeletal muscle mass loss is related to age. Mechanisms by which they interact have not been well established.
OBJECTIVE: To establish a relationship of age with serum levels of IGF-1, skeletal muscle and appendicular muscle mass index, and their influence in isokinetic parameters in osteoporotic female patients.
MATERIAL AND METHODS: Pearson correlation coefficient and linear regression analyses were used.
RESULTS: There were 38 patients with a mean age of 65.16 years (range: 50-84 years), mean appendicular skeletal mass index (ASMI) of 6.3 kg/m2 (range: 4.3-8.3) and mean skeletal mass index (SMI) of 12.4 kg/m2 (range: 9.6-15.7), mean serum IGF-1 levels of 82.97 ng/ml (range: 22-177). Linear regression predicted hip mineral bone density by SMI (p = 0.19) and age (p = 0.017, r = 0.50). Some isokinetic parameters had a positive correlation for work with age. Knee acceleration time had a positive correlation with age.
CONCLUSIONS: Osteoporosis and sarcopenia may have related pathophysiologic mechanisms. Growth factor study must include the influence of sex hormones. Some isokinetic parameters are determined by the predominant muscle fiber, skeletal mass index and age.