Literature DB >> 16454510

Role of Caco-2 cell monolayers in prediction of intestinal drug absorption.

Pranav Shah1, Viral Jogani, Tamishraha Bagchi, Ambikanandan Misra.   

Abstract

The usefulness of Caco-2 cell monolayers in determining the intestinal drug absorption of potential drug candidates as such and from delivery systems, elucidating the underlying mechanisms thereof, presystemic metabolism, cellular uptake and cytotoxicological assessment has been exemplified in this review. The role of Caco-2 cell monolayers in studying the effectiveness, involved mechanism and toxicity of various excipients for drug absorption promotion has also been discussed.

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Year:  2006        PMID： 16454510     DOI： 10.1021/bp050208u

Source DB:  PubMed          Journal:  Biotechnol Prog        ISSN： 1520-6033


  33 in total

1.  Comparison of intestinal absorption and disposition of structurally similar bioactive flavones in Radix Scutellariae.

Authors:  Chenrui Li; Li Zhang; Limin Zhou; Siu Kwan Wo; Ge Lin; Zhong Zuo
Journal:  AAPS J       Date:  2011-12-14       Impact factor: 4.009

2.  Intestinal epithelium is more susceptible to cytopathic injury and altered permeability than the lung epithelium in the context of acute sepsis.

Authors:  Mark W Julian; Shengying Bao; Daren L Knoell; Ruairi J Fahy; Guohong Shao; Elliott D Crouser
Journal:  Int J Exp Pathol       Date:  2011-08-13       Impact factor: 1.925

3.  In vitro-in situ permeability and dissolution of fexofenadine with kinetic modeling in the presence of sodium dodecyl sulfate.

Authors:  Evren Gundogdu; V Mangas-Sanjuan; Isabel Gonzalez-Alvarez; Marival Bermejo; Ercument Karasulu
Journal:  Eur J Drug Metab Pharmacokinet       Date:  2011-08-11       Impact factor: 2.441

4.  Exploiting the Acidic Extracellular pH: Evaluation of Streptococcus salivarius M18 Postbiotics to Target Cancer Cells.

Authors:  Sevinç Karaçam; Sinem Tunçer
Journal:  Probiotics Antimicrob Proteins       Date:  2021-06-02       Impact factor: 4.609

5.  Improvement of paracellular transport in the Caco-2 drug screening model using protein-engineered substrates.

Authors:  Rebecca L DiMarco; Daniel R Hunt; Ruby E Dewi; Sarah C Heilshorn
Journal:  Biomaterials       Date:  2017-03-18       Impact factor: 12.479

6.  Monocarboxylate transporter-mediated transport of gamma-hydroxybutyric acid in human intestinal Caco-2 cells.

Authors:  Wing Ki Lam; Melanie A Felmlee; Marilyn E Morris
Journal:  Drug Metab Dispos       Date:  2009-12-01       Impact factor: 3.922

7.  Homogeneous nanoparticles to enhance the efficiency of a hydrophobic drug, antihyperlipidemic probucol, characterized by solid-state NMR.

Authors:  Takeshi Io; Toshiro Fukami; Kazutoshi Yamamoto; Toyofumi Suzuki; Jiadi Xu; Kazuo Tomono; Ayyalusamy Ramamoorthy
Journal:  Mol Pharm       Date:  2010-02-01       Impact factor: 4.939

Review 8.  Assessment of the mode of action underlying development of rodent small intestinal tumors following oral exposure to hexavalent chromium and relevance to humans.

Authors:  Chad M Thompson; Deborah M Proctor; Mina Suh; Laurie C Haws; Christopher R Kirman; Mark A Harris
Journal:  Crit Rev Toxicol       Date:  2013-03       Impact factor: 5.635

9.  Functional and cytometric examination of different human lung epithelial cell types as drug transport barriers.

Authors:  Kyoung Ah Min; Gus R Rosania; Chong-Kook Kim; Meong Cheol Shin
Journal:  Arch Pharm Res       Date:  2016-01-08       Impact factor: 4.946

10.  Models and methods to evaluate transport of drug delivery systems across cellular barriers.

Authors:  Rasa Ghaffarian; Silvia Muro
Journal:  J Vis Exp       Date:  2013-10-17       Impact factor: 1.355
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