Literature DB >> 16453135

Intestinal mucositis: the role of the Bcl-2 family, p53 and caspases in chemotherapy-induced damage.

Joanne M Bowen1, Rachel J Gibson, Adrian G Cummins, Dorothy M K Keefe.   

Abstract

Intestinal mucositis occurs as a consequence of cytotoxic treatment through multiple mechanisms including induction of crypt cell death (apoptosis) and cytostasis. The molecular control of these actions throughout the gastrointestinal tract has yet to be fully elucidated; however, they are known to involve p53, the Bcl-2 family and caspases. This review will provide an overview of current research as well as identify areas where gaps in knowledge exist.

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Year:  2006        PMID： 16453135     DOI： 10.1007/s00520-005-0004-7

Source DB:  PubMed          Journal:  Support Care Cancer        ISSN： 0941-4355            Impact factor:   3.603


  207 in total

Review 1.  Serial killers: ordering caspase activation events in apoptosis.

Authors:  E A Slee; C Adrain; S J Martin
Journal:  Cell Death Differ       Date:  1999-11       Impact factor: 15.828

Review 2.  All along the watchtower: on the regulation of apoptosis regulators.

Authors:  B Fadeel; B Zhivotovsky; S Orrenius
Journal:  FASEB J       Date:  1999-10       Impact factor: 5.191

3.  Morphologic alterations induced by methotrexate in the mucosa of human proximal intestine. I. Serial observations by light microscopy.

Authors:  J S TRIER
Journal:  Gastroenterology       Date:  1962-03       Impact factor: 22.682

4.  Evidences of the involvement of Bak, a member of the Bcl-2 family of proteins, in active coeliac disease.

Authors:  Alejandra C Cherñavsky; Andrea E Rubio; Silvia Vanzulli; Natalia Rubinstein; Susana de Rosa; Leonardo Fainboim
Journal:  Autoimmunity       Date:  2002-02       Impact factor: 2.815

5.  Morphometric quantification of apoptotic stages in cell culture.

Authors:  Maurizio Sabbatini; Chiarella Bozzo; Mario Castellucci; Mario Cannas
Journal:  Cells Tissues Organs       Date:  2004       Impact factor: 2.481

6.  Identification of a p53-dependent negative response element in the bcl-2 gene.

Authors:  T Miyashita; M Harigai; M Hanada; J C Reed
Journal:  Cancer Res       Date:  1994-06-15       Impact factor: 12.701

7.  BCL-x(L) and BCL2 delay Myc-induced cell cycle entry through elevation of p27 and inhibition of G1 cyclin-dependent kinases.

Authors:  Courtney Greider; Anuja Chattopadhyay; Christina Parkhurst; Elizabeth Yang
Journal:  Oncogene       Date:  2002-11-07       Impact factor: 9.867

Review 8.  Cellular stress response and apoptosis in cancer therapy.

Authors:  I Herr; K M Debatin
Journal:  Blood       Date:  2001-11-01       Impact factor: 22.113

Review 9.  To die or not to die: how does p53 decide?

Authors:  Elizabeth A Slee; Daniel J O'Connor; Xin Lu
Journal:  Oncogene       Date:  2004-04-12       Impact factor: 9.867

10.  Bad, a heterodimeric partner for Bcl-XL and Bcl-2, displaces Bax and promotes cell death.

Authors:  E Yang; J Zha; J Jockel; L H Boise; C B Thompson; S J Korsmeyer
Journal:  Cell       Date:  1995-01-27       Impact factor: 41.582
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  32 in total

1.  Bortezomib-related colon mucositis in a multiple myeloma patient.

Authors:  Agostina Siniscalchi; Andrea Tendas; Micaela Ales; Stefano Fratoni; Luca Cupelli; Teresa Dentamaro; Laura Scaramucci; Marco Giovannini; Tommaso Caravita; Giuseppe Santeusanio; Pasquale Niscola; Paolo de Fabritiis
Journal:  Support Care Cancer       Date:  2009-01-27       Impact factor: 3.603

Review 2.  Mucosal injury from targeted anti-cancer therapy.

Authors:  Dorothy M K Keefe; Rachel J Gibson
Journal:  Support Care Cancer       Date:  2006-11-14       Impact factor: 3.603

3.  Probiotic factors partially prevent changes to caspases 3 and 7 activation and transepithelial electrical resistance in a model of 5-fluorouracil-induced epithelial cell damage.

Authors:  Luca D Prisciandaro; Mark S Geier; Ann E Chua; Ross N Butler; Adrian G Cummins; Guy R Sander; Gordon S Howarth
Journal:  Support Care Cancer       Date:  2012-04-20       Impact factor: 3.603

4.  The Mechanisms of the Anti-Inflammatory and Anti-Apoptotic Effects of Omega-3 Polyunsaturated Fatty Acids during Methotrexate-Induced Intestinal Damage in Cell Line and in a Rat Model.

Authors:  Tal Koppelmann; Yulia Pollak; Yoav Ben-Shahar; Gregory Gorelik; Igor Sukhotnik
Journal:  Nutrients       Date:  2021-03-10       Impact factor: 5.717

5.  Activation of p38-MAPK by CXCL4/CXCR3 axis contributes to p53-dependent intestinal apoptosis initiated by 5-fluorouracil.

Authors:  Jing Gao; Jin Gao; Lan Qian; Xia Wang; Mingyuan Wu; Yang Zhang; Hao Ye; Shunying Zhu; Yan Yu; Wei Han
Journal:  Cancer Biol Ther       Date:  2014-05-06       Impact factor: 4.742

6.  5-HT₃ receptor antagonists ameliorate 5-fluorouracil-induced intestinal mucositis by suppression of apoptosis in murine intestinal crypt cells.

Authors:  M Yasuda; S Kato; N Yamanaka; M Iimori; K Matsumoto; D Utsumi; Y Kitahara; K Amagase; S Horie; K Takeuchi
Journal:  Br J Pharmacol       Date:  2013-03       Impact factor: 8.739

7.  Induction of protein tyrosine kinase 6 in mouse intestinal crypt epithelial cells promotes DNA damage-induced apoptosis.

Authors:  Andrea Haegebarth; Ansu O Perekatt; Wenjun Bie; Jessica J Gierut; Angela L Tyner
Journal:  Gastroenterology       Date:  2009-06-06       Impact factor: 22.682

8.  Apoptotic and inflammation markers in oral mucositis in head and neck cancer patients receiving radiotherapy: preliminary report.

Authors:  Arsinoi Xanthinaki; Ourania Nicolatou-Galitis; Pavlina Athanassiadou; Maria Gonidi; Vassilis Kouloulias; Anastasia Sotiropoulou-Lontou; George Pissakas; Konstantinos Kyprianou; John Kouvaris; Efstratios Patsouris
Journal:  Support Care Cancer       Date:  2008-01-16       Impact factor: 3.603

9.  Dietary palmitic acid modulates intestinal re-growth after massive small bowel resection in a rat.

Authors:  Igor Sukhotnik; Lili Hayari; Yulia Bashenko; Elena Chemodanov; Jorge Mogilner; Raanan Shamir; Fabiana Bar Yosef; Ron Shaoul; Arnold G Coran
Journal:  Pediatr Surg Int       Date:  2008-12       Impact factor: 1.827

10.  Ursodeoxycholic acid attenuates 5-fluorouracil-induced mucositis in a rat model.

Authors:  Seung Han Kim; Hoon Jai Chun; Hyuk Soon Choi; Eun Sun Kim; Bora Keum; Yeon Seok Seo; Yoon Tae Jeen; Hong Sik Lee; Soon Ho Um; Chang Duck Kim
Journal:  Oncol Lett       Date:  2018-06-04       Impact factor: 2.967
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