Literature DB >> 16452446

Apyrase, the product of the virulence plasmid-encoded phoN2 (apy) gene of Shigella flexneri, is necessary for proper unipolar IcsA localization and for efficient intercellular spread.

D Santapaola1, F Del Chierico, A Petrucca, S Uzzau, M Casalino, B Colonna, R Sessa, F Berlutti, M Nicoletti.   

Abstract

The role in virulence of the Shigella flexneri ospB-phoN2 operon has been evaluated. Here we confirm that OspB is an effector and show that apyrase, the product of phoN2, may be a virulence factor, since it is required for efficient intercellular spreading. Apyrase may be important in a deoxynucleoside triphosphate-hydrolyzing activity-independent manner, suggesting that it may act as an interaction partner in the process of IcsA localization.

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Year:  2006        PMID： 16452446      PMCID： PMC1367242          DOI： 10.1128/JB.188.4.1620-1627.2006

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  42 in total

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2.  One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products.

Authors:  K A Datsenko; B L Wanner
Journal:  Proc Natl Acad Sci U S A       Date:  2000-06-06       Impact factor: 11.205

3.  Epitope tagging of chromosomal genes in Salmonella.

Authors:  S Uzzau; N Figueroa-Bossi; S Rubino; L Bossi
Journal:  Proc Natl Acad Sci U S A       Date:  2001-12-11       Impact factor: 11.205

4.  A sensitive silver stain for detecting lipopolysaccharides in polyacrylamide gels.

Authors:  C M Tsai; C E Frasch
Journal:  Anal Biochem       Date:  1982-01-01       Impact factor: 3.365

5.  The virulence plasmid pWR100 and the repertoire of proteins secreted by the type III secretion apparatus of Shigella flexneri.

Authors:  C Buchrieser; P Glaser; C Rusniok; H Nedjari; H D'Hauteville; F Kunst; P Sansonetti; C Parsot
Journal:  Mol Microbiol       Date:  2000-11       Impact factor: 3.501

6.  Enteroinvasive Escherichia coli virulence-plasmid-carried apyrase (apy) and ospB genes are organized as a bicistronic operon and are subject to differential expression.

Authors:  Daniela Santapaola; Mariassunta Casalino; Andrea Petrucca; Carlo Presutti; Carlo Zagaglia; Francesca Berlutti; Bianca Colonna; Mauro Nicoletti
Journal:  Microbiology       Date:  2002-08       Impact factor: 2.777

7.  MxiE regulates intracellular expression of factors secreted by the Shigella flexneri 2a type III secretion system.

Authors:  Colleen D Kane; Raymond Schuch; William A Day; Anthony T Maurelli
Journal:  J Bacteriol       Date:  2002-08       Impact factor: 3.490

8.  Identification of the cis-acting site involved in activation of promoters regulated by activity of the type III secretion apparatus in Shigella flexneri.

Authors:  Maria Mavris; Philippe J Sansonetti; Claude Parsot
Journal:  J Bacteriol       Date:  2002-12       Impact factor: 3.490

9.  Protein synthesis in HeLa or Henle 407 cells infected with Shigella dysenteriae 1, Shigella flexneri 2a, or Salmonella typhimurium W118.

Authors:  T L Hale; S B Formal
Journal:  Infect Immun       Date:  1981-04       Impact factor: 3.441

10.  Involvement of a plasmid in the invasive ability of Shigella flexneri.

Authors:  P J Sansonetti; D J Kopecko; S B Formal
Journal:  Infect Immun       Date:  1982-03       Impact factor: 3.441
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  18 in total

1.  Elongation factor P and modifying enzyme PoxA are necessary for virulence of Shigella flexneri.

Authors:  Hannah E Marman; Alexandra R Mey; Shelley M Payne
Journal:  Infect Immun       Date:  2014-06-16       Impact factor: 3.441

Review 2.  Molecular pathogenesis of Shigella spp.: controlling host cell signaling, invasion, and death by type III secretion.

Authors:  Gunnar N Schroeder; Hubert Hilbi
Journal:  Clin Microbiol Rev       Date:  2008-01       Impact factor: 26.132

3.  Bacteriophage 2851 is a prototype phage for dissemination of the Shiga toxin variant gene 2c in Escherichia coli O157:H7.

Authors:  Eckhard Strauch; Jens Andre Hammerl; Antje Konietzny; Susanne Schneiker-Bekel; Walter Arnold; Alexander Goesmann; Alfred Pühler; Lothar Beutin
Journal:  Infect Immun       Date:  2008-09-29       Impact factor: 3.441

4.  Analysis of Soluble protein complexes in Shigella flexneri reveals the influence of temperature on the amount of lipopolysaccharide.

Authors:  Chang Niu; Na Shang; Xiang Liao; Erling Feng; Xiankai Liu; Dongshu Wang; Jie Wang; Peitang Huang; Yuejin Hua; Li Zhu; Hengliang Wang
Journal:  Mol Cell Proteomics       Date:  2013-02-02       Impact factor: 5.911

5.  Signature-tagged mutagenesis of Edwardsiella ictaluri identifies virulence-related genes, including a salmonella pathogenicity island 2 class of type III secretion systems.

Authors:  Ronald L Thune; Denise H Fernandez; Jennifer L Benoit; Maria Kelly-Smith; Matthew L Rogge; Natha J Booth; Christie A Landry; Rachel A Bologna
Journal:  Appl Environ Microbiol       Date:  2007-10-26       Impact factor: 4.792

6.  The Shigella dysenteriae serotype 1 proteome, profiled in the host intestinal environment, reveals major metabolic modifications and increased expression of invasive proteins.

Authors:  Rembert Pieper; Quanshun Zhang; Prashanth P Parmar; Shih-Ting Huang; David J Clark; Hamid Alami; Arthur Donohue-Rolfe; Robert D Fleischmann; Scott N Peterson; Saul Tzipori
Journal:  Proteomics       Date:  2009-11       Impact factor: 3.984

7.  Shigella flexneri type III secretion system effectors OspB and OspF target the nucleus to downregulate the host inflammatory response via interactions with retinoblastoma protein.

Authors:  Daniel V Zurawski; Karen L Mumy; Christina S Faherty; Beth A McCormick; Anthony T Maurelli
Journal:  Mol Microbiol       Date:  2008-11-14       Impact factor: 3.501

8.  VirB alleviates H-NS repression of the icsP promoter in Shigella flexneri from sites more than one kilobase upstream of the transcription start site.

Authors:  Maria I Castellanos; Dustin J Harrison; Jennifer M Smith; Stephanie K Labahn; Karen M Levy; Helen J Wing
Journal:  J Bacteriol       Date:  2009-04-10       Impact factor: 3.490

9.  Outer membrane protein A (OmpA): a new player in shigella flexneri protrusion formation and inter-cellular spreading.

Authors:  Cecilia Ambrosi; Monica Pompili; Daniela Scribano; Carlo Zagaglia; Sandro Ripa; Mauro Nicoletti
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10.  VirB, a key transcriptional regulator of virulence plasmid genes in Shigella flexneri, forms DNA-binding site dependent foci in the bacterial cytoplasm.

Authors:  Jillian N Socea; Grant R Bowman; Helen J Wing
Journal:  J Bacteriol       Date:  2021-03-15       Impact factor: 3.490
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