Literature DB >> 16451222

Cell biology of the ghrelin receptor.

J P Camiña1.   

Abstract

Ghrelin, a gastric peptide involved in growth hormone release and energy homeostasis, is the endogenous ligand of the growth hormone secretagogue receptor type 1a (GHS-R1a), a G-protein coupled receptor mainly expressed in the pituitary and hypothalamus. This receptor mediates the main ghrelin-stimulated endocrine actions and some of the nonendocrine actions. However, a number of nonendocrine actions associated with ghrelin appear to be mediated by various GHS-R1a-related receptor subtypes, which are widely distributed in the central and peripheral tissues. This review summarises data concerning the localisation, regulation and function of GHS-R1a, as well as related receptors.

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Year:  2006        PMID： 16451222     DOI： 10.1111/j.1365-2826.2005.01379.x

Source DB:  PubMed          Journal:  J Neuroendocrinol        ISSN： 0953-8194            Impact factor:   3.627


  35 in total

Review 1.  Ghrelin: new molecular pathways modulating appetite and adiposity.

Authors:  Ruben Nogueiras; Lynda M Williams; Carlos Dieguez
Journal:  Obes Facts       Date:  2010-10-04       Impact factor: 3.942

Review 2.  G Protein-coupled Receptor Biased Agonism.

Authors:  Sima Y Hodavance; Clarice Gareri; Rachel D Torok; Howard A Rockman
Journal:  J Cardiovasc Pharmacol       Date:  2016-03       Impact factor: 3.105

3.  Ghrelin increases growth hormone production and functional expression of NaV1.1 and Na V1.2 channels in pituitary somatotropes.

Authors:  Adasue Magdaleno-Méndez; Belisario Domínguez; Araceli Rodríguez-Andrade; Manuel Barrientos-Morales; Patricia Cervantes-Acosta; Antonio Hernández-Beltrán; Ricardo González-Ramírez; Ricardo Felix
Journal:  Endocrine       Date:  2014-08-24       Impact factor: 3.633

4.  G Protein and β-arrestin signaling bias at the ghrelin receptor.

Authors:  Tama Evron; Sean M Peterson; Nikhil M Urs; Yushi Bai; Lauren K Rochelle; Marc G Caron; Larry S Barak
Journal:  J Biol Chem       Date:  2014-09-26       Impact factor: 5.157

5.  Hypotensive effects of ghrelin receptor agonists mediated through a novel receptor.

Authors:  Brid Callaghan; Samin Kosari; Ruslan V Pustovit; Daniela M Sartor; Dorota Ferens; Kung Ban; Jonathan Baell; Trung V Nguyen; Leni R Rivera; James A Brock; John B Furness
Journal:  Br J Pharmacol       Date:  2014-03       Impact factor: 8.739

6.  Ghrelin increases lymphocytes in chronic normobaric hypoxia.

Authors:  Fariba Mirzaie Bavil; Gisou Mohaddes; Hadi Ebrahimi; Rana Keyhanmanesh; Rafigheh Ghiyasi; Mohammad Reza Alipour
Journal:  Adv Pharm Bull       Date:  2014-08-10

7.  Combined estrogen and ghrelin administration restores number of blood vessels and collagen type I/III ratio in the urethral and anal canal submucosa of old ovariectomized rats.

Authors:  Diaa E E Rizk; Hazem A Hassan; Ahmed H Al-Marzouqi; Gaber A Ramadan; Soha S Al-Kedrah; Sayel A Daoud; Mohamed A Fahim
Journal:  Int Urogynecol J Pelvic Floor Dysfunct       Date:  2007-09-18

8.  Ghrelin receptor activity amplifies hippocampal N-methyl-d-aspartate receptor-mediated postsynaptic currents and increases phosphorylation of the GluN1 subunit at Ser896 and Ser897.

Authors:  Brandon G Muniz; Masako Isokawa
Journal:  Eur J Neurosci       Date:  2015-11-17       Impact factor: 3.386

9.  Regulation of ghrelin structure and membrane binding by phosphorylation.

Authors:  Eva Dehlin; Jianhua Liu; Samuel H Yun; Elizabeth Fox; Sandra Snyder; Cyrille Gineste; Leslie Willingham; Mario Geysen; Bruce D Gaylinn; Julianne J Sando
Journal:  Peptides       Date:  2008-02-13       Impact factor: 3.750

10.  Ghrelin triggers the synaptic incorporation of AMPA receptors in the hippocampus.

Authors:  Luís F Ribeiro; Tatiana Catarino; Sandra D Santos; Marion Benoist; J Fiona van Leeuwen; José A Esteban; Ana Luísa Carvalho
Journal:  Proc Natl Acad Sci U S A       Date:  2013-12-23       Impact factor: 11.205
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