OBJECTIVE: The apolipoprotein E (APOE) epsilon4 allele is a well-established factor associated with age-related macular degeneration (AMD). This disorder is characterized by a typical progressive central visual impairment. Our aim was to study further the relationship of the APOE genotype associated with AMD. MATERIALS AND METHODS: We evaluated a group of 95 patients with AMD and 65 controls. The APOE genotype for each participant in the study was determined. RESULTS: The allele was associated with age-related macular degeneration (OR = 5.6; 95% CI = 3.4-8.8 ; p < 0.001). Female patients with at least one epsilon4 allele had a significantly earlier age at diagnosis (epsilon4+ = 72.2 S.D. 5.1; epsilon4- = 78.8 +/- 5.7; p < 0.001). CONCLUSIONS: The APOE epsilon4 allele is not a protective factor for AMD, but is associated with an increased risk of its development.
OBJECTIVE: The apolipoprotein E (APOE) epsilon4 allele is a well-established factor associated with age-related macular degeneration (AMD). This disorder is characterized by a typical progressive central visual impairment. Our aim was to study further the relationship of the APOE genotype associated with AMD. MATERIALS AND METHODS: We evaluated a group of 95 patients with AMD and 65 controls. The APOE genotype for each participant in the study was determined. RESULTS: The allele was associated with age-related macular degeneration (OR = 5.6; 95% CI = 3.4-8.8 ; p < 0.001). Female patients with at least one epsilon4 allele had a significantly earlier age at diagnosis (epsilon4+ = 72.2 S.D. 5.1; epsilon4- = 78.8 +/- 5.7; p < 0.001). CONCLUSIONS: The APOE epsilon4 allele is not a protective factor for AMD, but is associated with an increased risk of its development.
Authors: Inés López-Cuenca; Elena Salobrar-García; Inés Gil-Salgado; Lidia Sánchez-Puebla; Lorena Elvira-Hurtado; José A Fernández-Albarral; Federico Ramírez-Toraño; Ana Barabash; Jaisalmer de Frutos-Lucas; Juan J Salazar; José M Ramírez; Ana I Ramírez; Rosa de Hoz Journal: J Pers Med Date: 2022-05-23
Authors: Gergely Losonczy; Attila Vajas; Lili Takács; Erika Dzsudzsák; Agnes Fekete; Eva Márhoffer; László Kardos; Eva Ajzner; Begoña Hurtado; Pablo Garcia de Frutos; András Berta; István Balogh Journal: PLoS One Date: 2012-11-29 Impact factor: 3.240