PURPOSE: This study focuses on a promising carrier system for imaging and therapeutic purposes using lipid nanocapsules. To assess their potential for clinical use, we labelled nanocapsules with (99m)Tc and (188)Re and analysed some kinetic biodistribution parameters after intravenous injection in rats. METHODS: Lipophilic complexes [(99m)Tc/(188)Re(S(3)CPh)(2)(S(2)CPh)] ((99m)Tc/(188)Re-SSS) were encapsulated within the nanoparticles during their manufacture with quantitative yield and satisfactory radiochemical purity. Rats were injected intravenously with 3.7 MBq (99m)Tc/(188)Re-labelled nanocapsules and sacrificed at 5, 15 and 30 min and 1, 2, 4, 8, 12, 16, 20 and 24 h. RESULTS: Dynamic scintigraphic acquisitions showed predominant hepatic uptake, and ex vivo counting indicated a long circulation time of labelled nanocapsules, with a half-life of 21+/-1 min for (99m)Tc and 22+/-2 min for (188)Re. Very weak urinary elimination was observed, indicating good stability of (99m)Tc and (188)Re labelling. CONCLUSION: (99m)Tc/(188)Re-SSS nanocapsules can be obtained with high yield and satisfactory radiochemical purity. The biodistributions of (99m)Tc/(188)Re-labelled nanocapsules are close to those of classical PEG-coated particles and show good stability of (188)Re/(99m)Tc-SSS labelling.
PURPOSE: This study focuses on a promising carrier system for imaging and therapeutic purposes using lipid nanocapsules. To assess their potential for clinical use, we labelled nanocapsules with (99m)Tc and (188)Re and analysed some kinetic biodistribution parameters after intravenous injection in rats. METHODS: Lipophilic complexes [(99m)Tc/(188)Re(S(3)CPh)(2)(S(2)CPh)] ((99m)Tc/(188)Re-SSS) were encapsulated within the nanoparticles during their manufacture with quantitative yield and satisfactory radiochemical purity. Rats were injected intravenously with 3.7 MBq (99m)Tc/(188)Re-labelled nanocapsules and sacrificed at 5, 15 and 30 min and 1, 2, 4, 8, 12, 16, 20 and 24 h. RESULTS: Dynamic scintigraphic acquisitions showed predominant hepatic uptake, and ex vivo counting indicated a long circulation time of labelled nanocapsules, with a half-life of 21+/-1 min for (99m)Tc and 22+/-2 min for (188)Re. Very weak urinary elimination was observed, indicating good stability of (99m)Tc and (188)Re labelling. CONCLUSION: (99m)Tc/(188)Re-SSS nanocapsules can be obtained with high yield and satisfactory radiochemical purity. The biodistributions of (99m)Tc/(188)Re-labelled nanocapsules are close to those of classical PEG-coated particles and show good stability of (188)Re/(99m)Tc-SSS labelling.
Authors: U O Häfeli; S Casillas; D W Dietz; G J Pauer; L A Rybicki; S D Conzone; D E Day Journal: Int J Radiat Oncol Biol Phys Date: 1999-04-01 Impact factor: 7.038
Authors: F D Chen; B T Hsieh; H E Wang; Y H Ou; W K Yang; J Whang-Peng; R S Liu; F F Knapp; G Ting; S H Yen Journal: Nucl Med Biol Date: 2001-10 Impact factor: 2.408
Authors: E Garin; N Noiret; C Malbert; N Lepareur; A Roucoux; S Caulet-Maugendre; A Moisan; J Lecloirec; J Y Herry; P Bourguet Journal: Eur J Nucl Med Mol Imaging Date: 2003-12-23 Impact factor: 9.236
Authors: Arnaud Béduneau; Patrick Saulnier; Nicolas Anton; François Hindré; Catherine Passirani; Holisoa Rajerison; Nicolas Noiret; Jean-Pierre Benoit Journal: Pharm Res Date: 2006-08-09 Impact factor: 4.200
Authors: G V Ullio Gamboa; S D Palma; A Lifschitz; M Ballent; C Lanusse; C Passirani; J P Benoit; D A Allemandi Journal: Parasitol Res Date: 2016-02-06 Impact factor: 2.289
Authors: E Allard; F Hindre; C Passirani; L Lemaire; N Lepareur; N Noiret; P Menei; J-P Benoit Journal: Eur J Nucl Med Mol Imaging Date: 2008-05-09 Impact factor: 9.236
Authors: Eric A Simone; Blaine J Zern; Ann-Marie Chacko; John L Mikitsh; Eric R Blankemeyer; Silvia Muro; Radu V Stan; Vladimir R Muzykantov Journal: Biomaterials Date: 2012-05-04 Impact factor: 12.479
Authors: Christina Tang; Jasmine Edelstein; John L Mikitsh; Edward Xiao; Aaron H Hemphill; Robert Pagels; Ann-Marie Chacko; Robert Prud'homme Journal: J Mater Chem B Date: 2016-03-03 Impact factor: 6.331
Authors: Nabila A El-Sheridy; Riham M El-Moslemany; Alyaa A Ramadan; Maged W Helmy; Labiba K El-Khordagui Journal: Drug Deliv Date: 2021-12 Impact factor: 6.819