BACKGROUND: An increased incidence of brain white-matter hyperintensities has been described in major depressive disorder, butthe impact of such hyperintensities on treatment outcome is still controversial. AIMS: To investigate the relationship of brain white-matter hyperintensities with cardiovascular risk factors and with treatment outcome in younger people with major depressive disorder. METHOD: We assessed brain white-matter hyperintensities and cardiovascular risk factors in 84 people with major depressive disorder prior to initiating antidepressant treatment. We also assessed hyperintensities in 35 matched controls. RESULTS: We found no significant difference in the prevalence of white-matter hyperintensities between the depression and the control groups. Left-hemisphere subcortical hyperintensities correlated with lower rates of treatment response. We found no correlation between global hyperintensity measures and clinical outcome. Brain white-matter hyperintensities correlated with hypertension and age and withtotal cardiovascular risk score. CONCLUSIONS: Subcortical white-matter hyperintensities in the left hemisphere (but notin other brain areas) maybe associated with poor response to antidepressant treatment in major depression.
BACKGROUND: An increased incidence of brain white-matter hyperintensities has been described in major depressive disorder, butthe impact of such hyperintensities on treatment outcome is still controversial. AIMS: To investigate the relationship of brain white-matter hyperintensities with cardiovascular risk factors and with treatment outcome in younger people with major depressive disorder. METHOD: We assessed brain white-matter hyperintensities and cardiovascular risk factors in 84 people with major depressive disorder prior to initiating antidepressant treatment. We also assessed hyperintensities in 35 matched controls. RESULTS: We found no significant difference in the prevalence of white-matter hyperintensities between the depression and the control groups. Left-hemisphere subcortical hyperintensities correlated with lower rates of treatment response. We found no correlation between global hyperintensity measures and clinical outcome. Brain white-matter hyperintensities correlated with hypertension and age and withtotal cardiovascular risk score. CONCLUSIONS: Subcortical white-matter hyperintensities in the left hemisphere (but notin other brain areas) maybe associated with poor response to antidepressant treatment in major depression.
Authors: Maria Conceição Grangeon; Camila Seixas; Lucas C Quarantini; Angela Miranda-Scippa; Maurizio Pompili; David C Steffens; Amy Wenzel; Acioly L T Lacerda; Irismar Reis de Oliveira Journal: CNS Spectr Date: 2010-06 Impact factor: 3.790
Authors: Wei Qiao Qiu; Jayandra J Himali; Philip A Wolf; D Charles DeCarli; Alexa Beiser; Rhoda Au Journal: Int J Geriatr Psychiatry Date: 2016-04-05 Impact factor: 3.485
Authors: Wouter S Hoogenboom; Roy H Perlis; Jordan W Smoller; Qing Zeng-Treitler; Vivian S Gainer; Shawn N Murphy; Susanne E Churchill; Isaac S Kohane; Martha E Shenton; Dan V Iosifescu Journal: Psychiatry Res Date: 2012-11-11 Impact factor: 3.222
Authors: Marcus V Zanetti; Maristela S Schaufelberger; Cláudio C de Castro; Paulo R Menezes; Márcia Scazufca; Philip K McGuire; Robin M Murray; Geraldo F Busatto Journal: Br J Psychiatry Date: 2008-07 Impact factor: 9.319