OBJECTIVE: This study tested whether behavioral disinhibition is more prevalent among offspring of parents with bipolar disorder than among offspring of parents without bipolar disorder. METHOD: The authors conducted a secondary analysis of data from a preexisting high-risk study of offspring at risk for panic disorder and depression (N=278) that had included some children with parents who had bipolar disorder (N=34). Children (ages 2-6) had been classified as behaviorally inhibited, disinhibited, or neither in laboratory assessments. RESULTS: Offspring of bipolar parents had significantly higher rates of behavioral disinhibition than offspring of parents without bipolar disorder. Behavioral inhibition did not differ between groups. Differences were not accounted for by parental panic disorder or major depression or by parental history of attention deficit hyperactivity disorder, conduct disorder, antisocial personality, or substance use disorders. CONCLUSIONS: Results suggest a familial link between bipolar disorder in parents and behavioral disinhibition in their offspring. Behavioral disinhibition may be a familially transmitted predisposing factor for dysregulatory distress later in life.
OBJECTIVE: This study tested whether behavioral disinhibition is more prevalent among offspring of parents with bipolar disorder than among offspring of parents without bipolar disorder. METHOD: The authors conducted a secondary analysis of data from a preexisting high-risk study of offspring at risk for panic disorder and depression (N=278) that had included some children with parents who had bipolar disorder (N=34). Children (ages 2-6) had been classified as behaviorally inhibited, disinhibited, or neither in laboratory assessments. RESULTS: Offspring of bipolar parents had significantly higher rates of behavioral disinhibition than offspring of parents without bipolar disorder. Behavioral inhibition did not differ between groups. Differences were not accounted for by parental panic disorder or major depression or by parental history of attention deficit hyperactivity disorder, conduct disorder, antisocial personality, or substance use disorders. CONCLUSIONS: Results suggest a familial link between bipolar disorder in parents and behavioral disinhibition in their offspring. Behavioral disinhibition may be a familially transmitted predisposing factor for dysregulatory distress later in life.
Authors: William Perry; Arpi Minassian; Brook Henry; Meegin Kincaid; Jared W Young; Mark A Geyer Journal: Psychiatry Res Date: 2010-05-14 Impact factor: 3.222
Authors: Maria A Oquendo; Steven P Ellis; Megan S Chesin; Boris Birmaher; Jamie Zelazny; Adrienne Tin; Nadine Melhem; Ainsley K Burke; David Kolko; Laurence Greenhill; Barbara Stanley; Beth S Brodsky; J John Mann; David A Brent Journal: Bipolar Disord Date: 2013-08-05 Impact factor: 6.744
Authors: Danella M Hafeman; John Merranko; David Axelson; Benjamin I Goldstein; Tina Goldstein; Kelly Monk; Mary Beth Hickey; Dara Sakolsky; Rasim Diler; Satish Iyengar; David Brent; David Kupfer; Boris Birmaher Journal: Am J Psychiatry Date: 2016-02-19 Impact factor: 18.112
Authors: Kathryn A Degnan; Amie Ashley Hane; Heather A Henderson; Olga Lydia Moas; Bethany C Reeb-Sutherland; Nathan A Fox Journal: Dev Psychol Date: 2011-05
Authors: Boris Birmaher; David Axelson; Benjamin Goldstein; Kelly Monk; Catherine Kalas; Mihaela Obreja; Mary Beth Hickey; Satish Iyengar; David Brent; Wael Shamseddeen; Rasim Diler; David Kupfer Journal: Am J Psychiatry Date: 2010-01-15 Impact factor: 18.112