Sharon J Gardiner1, Evan J Begg. 1. Department of Medicine, Christchurch School of Medicine and Christchurch Hospital, Christchurch, New Zealand. sharon.gardiner@cdhb.govt.nz
Abstract
BACKGROUND: Solid organ transplant recipients are usually advised against breastfeeding because of the questionable safety of immunosuppressants. Limited data suggest that infant exposure to tacrolimus via milk is low. This report characterizes the milk-to-blood ratio for tacrolimus using area under the concentration-time curve analysis in a renal transplant patient. CASE: A 29-year-old woman was exclusively breastfeeding her healthy 3-month-old infant while on tacrolimus 4 mg daily plus other drugs relevant to her transplant. The milk-to-blood ratio was 0.23, and average tacrolimus concentrations in milk were 1.8 microg/L. The baby ingested approximately 0.5% of the maternal dose (weight-adjusted). CONCLUSION: Infant exposure to tacrolimus in milk is very low, suggesting that maternal tacrolimus therapy may be compatible with breastfeeding.
BACKGROUND: Solid organ transplant recipients are usually advised against breastfeeding because of the questionable safety of immunosuppressants. Limited data suggest that infant exposure to tacrolimus via milk is low. This report characterizes the milk-to-blood ratio for tacrolimus using area under the concentration-time curve analysis in a renal transplant patient. CASE: A 29-year-old woman was exclusively breastfeeding her healthy 3-month-old infant while on tacrolimus 4 mg daily plus other drugs relevant to her transplant. The milk-to-blood ratio was 0.23, and average tacrolimus concentrations in milk were 1.8 microg/L. The baby ingested approximately 0.5% of the maternal dose (weight-adjusted). CONCLUSION:Infant exposure to tacrolimus in milk is very low, suggesting that maternal tacrolimus therapy may be compatible with breastfeeding.
Authors: Mary F Hebert; Songmao Zheng; Karen Hays; Danny D Shen; Connie L Davis; Jason G Umans; Menachem Miodovnik; Kenneth E Thummel; Thomas R Easterling Journal: Transplantation Date: 2013-04-15 Impact factor: 4.939
Authors: Cameron J McKinzie; Jillian P Casale; Jack C Guerci; Alyson Prom; Christina T Doligalski Journal: Paediatr Drugs Date: 2022-07-23 Impact factor: 3.930
Authors: Songmao Zheng; Thomas R Easterling; Karen Hays; Jason G Umans; Menachem Miodovnik; Shannon Clark; Justina C Calamia; Kenneth E Thummel; Danny D Shen; Connie L Davis; Mary F Hebert Journal: Br J Clin Pharmacol Date: 2013-12 Impact factor: 4.335
Authors: Jarosław Kalinka; Maria Szubert; Andrzej Zdziennicki; Krzysztof Chojnowski; Marek Maciejewski; Katarzyna Piestrzeniewicz; Michał Zakliczyński; Jarosław Drożdż Journal: Kardiochir Torakochirurgia Pol Date: 2014-09-28