Literature DB >> 16448801

Virulence comparison in mice of distinct isolates of type A Francisella tularensis.

Susan M Twine1, Hua Shen, John F Kelly, Wangxue Chen, Anders Sjöstedt, J Wayne Conlan.   

Abstract

Francisella tularensis subspecies tularensis (type A F. tularensis) is considered to be one of the most virulent of all bacterial pathogens. Mice are extremely susceptible to infection with this subspecies (LD100 via various inoculation routes is <10 cfu). However, it has not been established whether overt virulence differences exist amongst type A strains of F. tularensis. To this end, the present study compared the virulence of two distinct type A strains, FSC033 and SCHU S4, for naïve mice and mice immunized with the live vaccine strain of the pathogen, F. tularensis LVS. One nominal isolate of SCHU S4 was found to be completely avirulent. Another isolate was highly virulent, but all examined cases appeared somewhat less virulent than FSC033. The implication of these findings for future infection and immunity studies is discussed.

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Year:  2006        PMID： 16448801      PMCID： PMC1868512          DOI： 10.1016/j.micpath.2005.12.004

Source DB:  PubMed          Journal:  Microb Pathog        ISSN： 0882-4010            Impact factor:   3.738


  23 in total

1.  A mutant of Francisella tularensis strain SCHU S4 lacking the ability to express a 58-kilodalton protein is attenuated for virulence and is an effective live vaccine.

Authors:  Susan Twine; Mona Byström; Wangxue Chen; Mats Forsman; Igor Golovliov; Anders Johansson; John Kelly; Helena Lindgren; Kerstin Svensson; Carl Zingmark; Wayne Conlan; Anders Sjöstedt
Journal:  Infect Immun       Date:  2005-12       Impact factor: 3.441

2.  Role of antibody to lipopolysaccharide in protection against low- and high-virulence strains of Francisella tularensis.

Authors:  M Fulop; P Mastroeni; M Green; R W Titball
Journal:  Vaccine       Date:  2001-08-14       Impact factor: 3.641

3.  Evaluation of PCR-based methods for discrimination of Francisella species and subspecies and development of a specific PCR that distinguishes the two major subspecies of Francisella tularensis.

Authors:  A Johansson; A Ibrahim; I Göransson; U Eriksson; D Gurycova; J E Clarridge; A Sjöstedt
Journal:  J Clin Microbiol       Date:  2000-11       Impact factor: 5.948

Review 4.  Tularemia as a biological weapon: medical and public health management.

Authors:  D T Dennis; T V Inglesby; D A Henderson; J G Bartlett; M S Ascher; E Eitzen; A D Fine; A M Friedlander; J Hauer; M Layton; S R Lillibridge; J E McDade; M T Osterholm; T O'Toole; G Parker; T M Perl; P K Russell; K Tonat
Journal:  JAMA       Date:  2001-06-06       Impact factor: 56.272

5.  The complete genome sequence of Francisella tularensis, the causative agent of tularemia.

Authors:  Pär Larsson; Petra C F Oyston; Patrick Chain; May C Chu; Melanie Duffield; Hans-Henrik Fuxelius; Emilio Garcia; Greger Hälltorp; Daniel Johansson; Karen E Isherwood; Peter D Karp; Eva Larsson; Ying Liu; Stephen Michell; Joann Prior; Richard Prior; Stephanie Malfatti; Anders Sjöstedt; Kerstin Svensson; Nick Thompson; Lisa Vergez; Jonathan K Wagg; Brendan W Wren; Luther E Lindler; Siv G E Andersson; Mats Forsman; Richard W Titball
Journal:  Nat Genet       Date:  2005-01-09       Impact factor: 38.330

6.  Aerosol-, but not intradermal-immunization with the live vaccine strain of Francisella tularensis protects mice against subsequent aerosol challenge with a highly virulent type A strain of the pathogen by an alphabeta T cell- and interferon gamma- dependent mechanism.

Authors:  J Wayne Conlan; Hua Shen; Rhonda Kuolee; Xigeng Zhao; Wangxue Chen
Journal:  Vaccine       Date:  2005-03-31       Impact factor: 3.641

7.  Experimental tularemia in mice challenged by aerosol or intradermally with virulent strains of Francisella tularensis: bacteriologic and histopathologic studies.

Authors:  J Wayne Conlan; Wangxue Chen; Hua Shen; Ann Webb; Rhonda KuoLee
Journal:  Microb Pathog       Date:  2003-05       Impact factor: 3.738

8.  Susceptibility of immunodeficient mice to aerosol and systemic infection with virulent strains of Francisella tularensis.

Authors:  Wangxue Chen; Rhonda KuoLee; Hua Shen; J Wayne Conlan
Journal:  Microb Pathog       Date:  2004-06       Impact factor: 3.738

9.  Tularemia in BALB/c and C57BL/6 mice vaccinated with Francisella tularensis LVS and challenged intradermally, or by aerosol with virulent isolates of the pathogen: protection varies depending on pathogen virulence, route of exposure, and host genetic background.

Authors:  Wangxue Chen; Hua Shen; Ann Webb; Rhonda KuoLee; J Wayne Conlan
Journal:  Vaccine       Date:  2003-09-08       Impact factor: 3.641

10.  Antimicrobial susceptibility testing of Francisella tularensis with a modified Mueller-Hinton broth.

Authors:  C N Baker; D G Hollis; C Thornsberry
Journal:  J Clin Microbiol       Date:  1985-08       Impact factor: 5.948
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  28 in total

1.  Genetic identification of unique immunological responses in mice infected with virulent and attenuated Francisella tularensis.

Authors:  Luke C Kingry; Ryan M Troyer; Nicole L Marlenee; Helle Bielefeldt-Ohmann; Richard A Bowen; Alan R Schenkel; Steven W Dow; Richard A Slayden
Journal:  Microbes Infect       Date:  2010-11-09       Impact factor: 2.700

2.  Mouse model of oral infection with virulent type A Francisella tularensis.

Authors:  R KuoLee; X Zhao; J Austin; G Harris; J W Conlan; W Chen
Journal:  Infect Immun       Date:  2007-01-22       Impact factor: 3.441

3.  Lack of in vitro and in vivo recognition of Francisella tularensis subspecies lipopolysaccharide by Toll-like receptors.

Authors:  Adeline M Hajjar; Megan D Harvey; Scott A Shaffer; David R Goodlett; Anders Sjöstedt; Helen Edebro; Mats Forsman; Mona Byström; Mark Pelletier; Christopher B Wilson; Samuel I Miller; Shawn J Skerrett; Robert K Ernst
Journal:  Infect Immun       Date:  2006-09-18       Impact factor: 3.441

4.  Identification of a dominant CD4 T cell epitope in the membrane lipoprotein Tul4 from Francisella tularensis LVS.

Authors:  Michael D Valentino; Lucinda L Hensley; Denise Skrombolas; Pamela L McPherson; Matthew D Woolard; Thomas H Kawula; Jeffrey A Frelinger; John G Frelinger
Journal:  Mol Immunol       Date:  2009-02-23       Impact factor: 4.407

5.  Oral live vaccine strain-induced protective immunity against pulmonary Francisella tularensis challenge is mediated by CD4+ T cells and antibodies, including immunoglobulin A.

Authors:  Heather J Ray; Yu Cong; Ashlesh K Murthy; Dale M Selby; Karl E Klose; Jeffrey R Barker; M Neal Guentzel; Bernard P Arulanandam
Journal:  Clin Vaccine Immunol       Date:  2009-02-11

Review 6.  An approach to the identification of T cell epitopes in the genomic era: application to Francisella tularensis.

Authors:  Michael Valentino; John Frelinger
Journal:  Immunol Res       Date:  2009-02-11       Impact factor: 2.829

7.  Virulence differences among Francisella tularensis subsp. tularensis clades in mice.

Authors:  Claudia R Molins; Mark J Delorey; Brook M Yockey; John W Young; Sarah W Sheldon; Sara M Reese; Martin E Schriefer; Jeannine M Petersen
Journal:  PLoS One       Date:  2010-04-16       Impact factor: 3.240

8.  Identification of immunologic and pathologic parameters of death versus survival in respiratory tularemia.

Authors:  Damiana Chiavolini; Joseph Alroy; Carol A King; Peter Jorth; Susan Weir; Guillermo Madico; John R Murphy; Lee M Wetzler
Journal:  Infect Immun       Date:  2007-11-19       Impact factor: 3.441

9.  Vaccination with a defined Francisella tularensis subsp. novicida pathogenicity island mutant (DeltaiglB) induces protective immunity against homotypic and heterotypic challenge.

Authors:  Yu Cong; Jieh-Juen Yu; M Neal Guentzel; Michael T Berton; Janakiram Seshu; Karl E Klose; Bernard P Arulanandam
Journal:  Vaccine       Date:  2009-08-03       Impact factor: 3.641

10.  Glycogen synthase kinase-3beta (GSK3beta) inhibition suppresses the inflammatory response to Francisella infection and protects against tularemia in mice.

Authors:  Ping Zhang; Jenny Katz; Suzanne M Michalek
Journal:  Mol Immunol       Date:  2008-10-17       Impact factor: 4.407
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