BACKGROUND: Chronic drug use is associated with increased impulsivity, risky decision making, and impaired behavioral control, but the underlying mechanisms of this neurocognitive profile remain unclear. We investigated impulsive responding in the context of decision making, using a novel behavioral measure of reflection impulsivity: the tendency to gather and evaluate information before making a decision. METHODS: The Information Sampling Task was administered to current substance users dependent on amphetamines (n = 24) or opiates (n = 40), former users of amphetamines or opiates abstinent for at least 1 year (n = 24), and non-drug-using control subjects (n = 26). RESULTS: Current users of amphetamines and opiates sampled less information than control subjects and responded at a lower probability of making a correct response. Amphetamine- and opiate-dependent subjects did not differ. Reduced reflection was also apparent in the former substance users, who did not differ from the current users. Questionnaire ratings of impulsivity (on the Barratt Impulsivity Scale, version 11) were also inflated in three groups of substance users but were not significantly correlated with performance on the behavioral task. CONCLUSIONS: Reduced reflection is suggested to represent a cognitive marker for substance dependence that does not recover with prolonged abstinence and is associated with multiple drugs of abuse.
BACKGROUND: Chronic drug use is associated with increased impulsivity, risky decision making, and impaired behavioral control, but the underlying mechanisms of this neurocognitive profile remain unclear. We investigated impulsive responding in the context of decision making, using a novel behavioral measure of reflection impulsivity: the tendency to gather and evaluate information before making a decision. METHODS: The Information Sampling Task was administered to current substance users dependent on amphetamines (n = 24) or opiates (n = 40), former users of amphetamines or opiates abstinent for at least 1 year (n = 24), and non-drug-using control subjects (n = 26). RESULTS: Current users of amphetamines and opiates sampled less information than control subjects and responded at a lower probability of making a correct response. Amphetamine- and opiate-dependent subjects did not differ. Reduced reflection was also apparent in the former substance users, who did not differ from the current users. Questionnaire ratings of impulsivity (on the Barratt Impulsivity Scale, version 11) were also inflated in three groups of substance users but were not significantly correlated with performance on the behavioral task. CONCLUSIONS: Reduced reflection is suggested to represent a cognitive marker for substance dependence that does not recover with prolonged abstinence and is associated with multiple drugs of abuse.
Authors: Nadia Solowij; Katy A Jones; Megan E Rozman; Sasha M Davis; Joseph Ciarrochi; Patrick C L Heaven; Nicole Pesa; Dan I Lubman; Murat Yücel Journal: Psychopharmacology (Berl) Date: 2011-09-21 Impact factor: 4.530
Authors: Warren K Bickel; David P Jarmolowicz; E Terry Mueller; Kirstin M Gatchalian; Samuel M McClure Journal: Psychopharmacology (Berl) Date: 2012-03-24 Impact factor: 4.530
Authors: Melissa M Andrews; Shashwath A Meda; Andre D Thomas; Marc N Potenza; John H Krystal; Patrick Worhunsky; Michael C Stevens; Stephanie O'Malley; Gregory A Book; Brady Reynolds; Godfrey D Pearlson Journal: Biol Psychiatry Date: 2010-12-03 Impact factor: 13.382
Authors: Katia Befort; Megan K Mahoney; Carmen Chow; Scott J Hayton; Brigitte L Kieffer; Mary C Olmstead Journal: Psychopharmacology (Berl) Date: 2010-12-23 Impact factor: 4.530
Authors: L Joos; A E Goudriaan; L Schmaal; N A J De Witte; W Van den Brink; B G C Sabbe; G Dom Journal: Psychopharmacology (Berl) Date: 2012-10-25 Impact factor: 4.530