Thomas Olschewski1, Michael Heinrich Seegenschmiedt. 1. Department of Radiotherapy and Radiation Oncology, Alfried Krupp Krankenhaus, Alfried-Krupp-Strasse 21, 45117 Essen, Germany. bernd-pothmann@krupp-krankenhaus.de
Abstract
PURPOSE: To examine the role of radiotherapy (RT) in adult Langerhans cell histiocytosis (LCH) for osseous manifestations, to define open questions regarding RT, and to develop recommendations for the clinical decision-making and problem-solving process. MATERIAL AND METHODS: A literature review using different medical databases was conducted including the last 3 decades, and resulting questions regarding the use of ionizing radiation were systematically compiled. RESULTS: The literature review revealed a local control rate of 96% (93% complete remissions) in patients with osseous single-system disease and of 92% (76% complete remissions) in patients with bony involvement in multi-system disease. To increase our knowledge, a prospective registry has been developed to allow a differentiated analysis of RT outcome and definition of potential prognostic factors. CONCLUSION: Ionizing radiation can be successfully applied as a single treatment or in combination with other therapies for osseous manifestations of LCH. It leads to high remission and local control rates. Nevertheless, many open questions still exist. A prospective clinical registry is proposed to define the exact role of RT in this disease and to develop future interdisciplinary treatment guidelines.
PURPOSE: To examine the role of radiotherapy (RT) in adult Langerhans cell histiocytosis (LCH) for osseous manifestations, to define open questions regarding RT, and to develop recommendations for the clinical decision-making and problem-solving process. MATERIAL AND METHODS: A literature review using different medical databases was conducted including the last 3 decades, and resulting questions regarding the use of ionizing radiation were systematically compiled. RESULTS: The literature review revealed a local control rate of 96% (93% complete remissions) in patients with osseous single-system disease and of 92% (76% complete remissions) in patients with bony involvement in multi-system disease. To increase our knowledge, a prospective registry has been developed to allow a differentiated analysis of RT outcome and definition of potential prognostic factors. CONCLUSION:Ionizing radiation can be successfully applied as a single treatment or in combination with other therapies for osseous manifestations of LCH. It leads to high remission and local control rates. Nevertheless, many open questions still exist. A prospective clinical registry is proposed to define the exact role of RT in this disease and to develop future interdisciplinary treatment guidelines.
Authors: Jan Kriz; Hans Theodor Eich; Frank Bruns; Reinhard Heyd; Ulrich Schäfer; Uwe Haverkamp; Jens Büntzel; Heinrich Seegenschmiedt; Oliver Micke Journal: Radiat Oncol Date: 2013-10-09 Impact factor: 3.481
Authors: Clayton B Hess; Tony Y Eng; Tahseen H Nasti; Vishal R Dhere; Troy J Kleber; Jeffrey M Switchenko; Brent D Weinberg; Nadine Rouphael; Sibo Tian; Soumon Rudra; Luisa S Taverna; Alvaro Perez Daisson; Rafi Ahmed; Mohammad K Khan Journal: Radiother Oncol Date: 2021-10-13 Impact factor: 6.280