Literature DB >> 16443822

AMPK: a key sensor of fuel and energy status in skeletal muscle.

D Grahame Hardie1, Kei Sakamoto.   

Abstract

Contraction induces marked metabolic changes in muscle, and the AMP-activated protein kinase (AMPK) is a good candidate to explain these effects. Recent work using a muscle-specific knockout of the upstream kinase, LKB1, has confirmed that the LKB1-->AMPK cascade is the signaling pathway responsible for many of these effects.

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Year:  2006        PMID： 16443822     DOI： 10.1152/physiol.00044.2005

Source DB:  PubMed          Journal:  Physiology (Bethesda)        ISSN： 1548-9221


  159 in total

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