Literature DB >> 16443761

CART regulates islet hormone secretion and is expressed in the beta-cells of type 2 diabetic rats.

Nils Wierup1, Maria Björkqvist, Michael J Kuhar, Hindrik Mulder, Frank Sundler.   

Abstract

Cocaine- and amphetamine-regulated transcript (CART) is an anorexigenic peptide widely expressed in the central, peripheral, and enteric nervous systems. CART is also expressed in endocrine cells, including beta-cells during rat development and delta-cells of adult rats. We examined the effect of CART 55-102 on islet hormone secretion, using INS-1(832/13) cells and isolated rat islets. In addition, islet CART expression was examined in two rat models of type 2 diabetes: Goto-Kakizaki (GK) rats and dexamethasone (DEX)-treated rats. At high glucose, CART potentiated cAMP-enhanced insulin secretion via the cAMP/protein kinase A-dependent pathway. In the absence of cAMP-elevating agents, CART was without effect on INS-1 cells but modestly inhibited secretion of insulin, glucagon, and somatostatin from isolated islets. CART was markedly upregulated in the beta-cells of both diabetes models. Thus, in DEX-treated rats, islet CART mRNA expression, and the number of CART-immunoreactive beta-cells were 10-fold higher than in control rats. In GK rats, the relative number of CART-expressing beta-cells was 30-fold higher than in control rats. We conclude that CART is a regulator of islet hormone secretion and that CART is upregulated in the beta-cells of type 2 diabetic rats.

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Year:  2006        PMID： 16443761     DOI： 10.2337/diabetes.55.02.06.db04-1383

Source DB:  PubMed          Journal:  Diabetes        ISSN： 0012-1797            Impact factor:   9.461


  20 in total

1.  Mitochondrial mechanism of neuroprotection by CART.

Authors:  Peizhong Mao; Ardi Ardeshiri; Rachel Jacks; Sufang Yang; Patricia D Hurn; Nabil J Alkayed
Journal:  Eur J Neurosci       Date:  2007-07-18       Impact factor: 3.386

Review 2.  CART peptides: regulators of body weight, reward and other functions.

Authors:  G Rogge; D Jones; G W Hubert; Y Lin; M J Kuhar
Journal:  Nat Rev Neurosci       Date:  2008-10       Impact factor: 34.870

3.  RNAi-mediated silencing of prohormone convertase (PC) 5/6 expression leads to impairment in processing of cocaine- and amphetamine-regulated transcript (CART) precursor.

Authors:  Jeffrey Stein; Rohan Shah; Donald F Steiner; Arunangsu Dey
Journal:  Biochem J       Date:  2006-11-15       Impact factor: 3.857

4.  HIV therapy, metabolic and cardiovascular health are associated with glomerular hyperfiltration among men with and without HIV infection.

Authors:  Derek K Ng; Lisa P Jacobson; Todd T Brown; Frank J Palella; Jeremy J Martinson; Robert Bolan; Edgar R Miller; George J Schwartz; Alison G Abraham; Michelle M Estrella
Journal:  AIDS       Date:  2014-01-28       Impact factor: 4.177

5.  Cocaine- and amphetamine-regulated transcript (CART) protects beta cells against glucotoxicity and increases cell proliferation.

Authors:  Ramasri Sathanoori; Björn Olde; David Erlinge; Olga Göransson; Nils Wierup
Journal:  J Biol Chem       Date:  2012-12-16       Impact factor: 5.157

6.  The role of rosiglitazone treatment in the modulation of islet hormones and hormone-like peptides: a combined in situ hybridization and immunohistochemical study.

Authors:  Sukriye Yildirim; Sema Bolkent; Frank Sundler
Journal:  J Mol Histol       Date:  2008-11-08       Impact factor: 2.611

7.  A gene expression network model of type 2 diabetes links cell cycle regulation in islets with diabetes susceptibility.

Authors:  Mark P Keller; YounJeong Choi; Ping Wang; Dawn Belt Davis; Mary E Rabaglia; Angie T Oler; Donald S Stapleton; Carmen Argmann; Kathy L Schueler; Steve Edwards; H Adam Steinberg; Elias Chaibub Neto; Robert Kleinhanz; Scott Turner; Marc K Hellerstein; Eric E Schadt; Brian S Yandell; Christina Kendziorski; Alan D Attie
Journal:  Genome Res       Date:  2008-03-17       Impact factor: 9.043

8.  Cocaine- and amphetamine-regulated transcript peptide (CARTp): distribution and function in rat urinary bladder.

Authors:  K Zvarova; G M Herrera; V May; M A Vizzard
Journal:  J Mol Neurosci       Date:  2014-04-17       Impact factor: 3.444

9.  Beta cell chromogranin B is partially segregated in distinct granules and can be released separately from insulin in response to stimulation.

Authors:  T Giordano; C Brigatti; P Podini; E Bonifacio; J Meldolesi; M L Malosio
Journal:  Diabetologia       Date:  2008-04-24       Impact factor: 10.122

10.  CART is overexpressed in human type 2 diabetic islets and inhibits glucagon secretion and increases insulin secretion.

Authors:  Mia Abels; Matteo Riva; Hedvig Bennet; Emma Ahlqvist; Oleg Dyachok; Vini Nagaraj; Liliya Shcherbina; Rikard G Fred; Wenny Poon; Maria Sörhede-Winzell; Joao Fadista; Andreas Lindqvist; Lena Kask; Ramasri Sathanoori; Marloes Dekker-Nitert; Michael J Kuhar; Bo Ahrén; Claes B Wollheim; Ola Hansson; Anders Tengholm; Malin Fex; Erik Renström; Leif Groop; Valeriya Lyssenko; Nils Wierup
Journal:  Diabetologia       Date:  2016-06-23       Impact factor: 10.122
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