Jinsong Liu1, Xian Qiao, Jiande D Z Chen. 1. Division of Gastroenterology, University of Texas Medical Branch, GI Research, Route 0632, Room 221, Microbiology Building, 1108 The Strand, Galveston, TX 77555-0632, USA.
Abstract
BACKGROUND: The aims of this study were to investigate the effects and mechanisms of a novel method of gastric electrical stimulation on the prevention of vasopressin-induced emetic response and gastric dysrhythmias. METHODS: Fifteen dogs (10 normal, 5 vagotomized) chronically implanted with gastric serosal electrodes were used in a 3-session study (vasopressin, vasopressin plus 2-channel stimulation [DCS], and vasopressin plus dual-pulse stimulation [DPS]). RESULTS: Vasopressin induced gastric dysrhythmias and motion sickness-like symptoms (P < .05) and these effects were blocked partially with vagotomy. Both methods of DCS and DPS were capable of preventing vasopressin-induced gastric dysrhythmias (P < .05) and motion sickness-like symptoms (P < .05). The antiemetic effects of the proposed methods of DCS and DPS were abolished by vagotomy but their antidysrhythmic effects were not blocked by vagotomy. CONCLUSIONS: DCS and DPS are able to reduce vasopressin-induced gastric dysrhythmia and symptoms of nausea and vomiting. The vagal pathway is involved in the antiemetic effect but not the antidysrhythmic effect of the proposed methods of stimulation.
BACKGROUND: The aims of this study were to investigate the effects and mechanisms of a novel method of gastric electrical stimulation on the prevention of vasopressin-induced emetic response and gastric dysrhythmias. METHODS: Fifteen dogs (10 normal, 5 vagotomized) chronically implanted with gastric serosal electrodes were used in a 3-session study (vasopressin, vasopressin plus 2-channel stimulation [DCS], and vasopressin plus dual-pulse stimulation [DPS]). RESULTS: Vasopressin induced gastric dysrhythmias and motion sickness-like symptoms (P < .05) and these effects were blocked partially with vagotomy. Both methods of DCS and DPS were capable of preventing vasopressin-induced gastric dysrhythmias (P < .05) and motion sickness-like symptoms (P < .05). The antiemetic effects of the proposed methods of DCS and DPS were abolished by vagotomy but their antidysrhythmic effects were not blocked by vagotomy. CONCLUSIONS: DCS and DPS are able to reduce vasopressin-induced gastric dysrhythmia and symptoms of nausea and vomiting. The vagal pathway is involved in the antiemetic effect but not the antidysrhythmic effect of the proposed methods of stimulation.
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