Literature DB >> 16442288

Hydantoin derivatives as non-peptidic inhibitors of Ras farnesyl transferase.

Jinho Lee1, Jonghyun Kim, Jong Sung Koh, Hyun-Ho Chung, Kyoung-Hee Kim.   

Abstract

1,3,5,5-Tetrasubstituted 2,4-imidazolinedione (hydantoin) derivatives were evaluated as Ftase inhibitors. Potent Ftase inhibitors without thiol or peptide were obtained in three steps.

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Year:  2006        PMID： 16442288     DOI： 10.1016/j.bmcl.2005.12.074

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  3 in total

1.  Synthesis and in vitro cytotoxic evaluation of novel diazaspiro bicyclo hydantoin derivatives in human leukemia cells: a SAR study.

Authors:  C S Ananda Kumar; C V Kavitha; K Vinaya; S B Benaka Prasad; N R Thimmegowda; S Chandrappa; Sathees C Raghavan; K S Rangappa
Journal:  Invest New Drugs       Date:  2008-10-07       Impact factor: 3.850

2.  The role of aryl-topology in balancing between selective and dual 5-HT7R/5-HT1A actions of 3,5-substituted hydantoins.

Authors:  Katarzyna Kucwaj-Brysz; Rafał Kurczab; Ewa Żesławska; Annamaria Lubelska; Małgorzata Anna Marć; Gniewomir Latacz; Grzegorz Satała; Wojciech Nitek; Katarzyna Kieć-Kononowicz; Jadwiga Handzlik
Journal:  Medchemcomm       Date:  2018-05-08       Impact factor: 3.597

Review 3.  5-Ene-4-thiazolidinones - An efficient tool in medicinal chemistry.

Authors:  Danylo Kaminskyy; Anna Kryshchyshyn; Roman Lesyk
Journal:  Eur J Med Chem       Date:  2017-09-20       Impact factor: 6.514
  3 in total

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