| Literature DB >> 16442103 |
Shigeki Oshima1, Shin Onodera, Norio Amizuka, Minqi Li, Kazuharu Irie, Satoshi Watanabe, Yoshikazu Koyama, Jun Nishihira, Kazunori Yasuda, Akio Minami.
Abstract
A link between macrophage migration inhibitory factor (MIF) and estrogen has recently emerged. We examined the involvement of MIF in osteoporotic changes in bone after ovariectomy (OVX), and revealed that MIF-deficient mice (MIF-KO) were completely protected from this phenomenon. The increase in osteoclast number per bone surface and serum IL-1beta levels, which were observed in wild-type mice after OVX, did not occur in MIF KO. Our data suggest that MIF plays an important role in the pathogenesis of postmenopausal osteoporosis, and could be a novel target for the treatment of this disease.Entities:
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Year: 2006 PMID： 16442103 DOI： 10.1016/j.febslet.2006.01.038
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124