INTRODUCTION: The purpose of this study was to test a hypothesis of increased urinary excretion of uric acid as an indicator of adenosine triphosphate (ATP) degradation in adult patients with acute respiratory failure, and to look for a correlation to the clinical outcome. STUDY DESIGN: Prospectively 31 patients with acute respiratory failure were studied. The patients were divided into two groups according to the clinical outcome: the need for solely supplemental oxygen (group 1), death or mechanical ventilation (group 2). METHODS: Uric acid was determined by spectrophotometry. RESULTS: Mean uric acid excretion was 39 mumol/kg (range, 7 to 92 mumol/kg) body weight/per 24 h in group 1 (16 patients) compared with 65 mumol/kg/24 h (range, 8 to 253 mumol/kg/24 h) in group 2 (13 patients were mechanically ventilated, and two patients died). The difference was highly significant (p less than 0.0001). CONCLUSION: Increased amount of urinary uric acid was related to the severity of acute respiratory failure in adults.
INTRODUCTION: The purpose of this study was to test a hypothesis of increased urinary excretion of uric acid as an indicator of adenosine triphosphate (ATP) degradation in adult patients with acute respiratory failure, and to look for a correlation to the clinical outcome. STUDY DESIGN: Prospectively 31 patients with acute respiratory failure were studied. The patients were divided into two groups according to the clinical outcome: the need for solely supplemental oxygen (group 1), death or mechanical ventilation (group 2). METHODS:Uric acid was determined by spectrophotometry. RESULTS: Mean uric acid excretion was 39 mumol/kg (range, 7 to 92 mumol/kg) body weight/per 24 h in group 1 (16 patients) compared with 65 mumol/kg/24 h (range, 8 to 253 mumol/kg/24 h) in group 2 (13 patients were mechanically ventilated, and two patients died). The difference was highly significant (p less than 0.0001). CONCLUSION: Increased amount of urinary uric acid was related to the severity of acute respiratory failure in adults.
Authors: Kris M Mogensen; Jessica Lasky-Su; Angela J Rogers; Rebecca M Baron; Laura E Fredenburgh; James Rawn; Malcolm K Robinson; Anthony Massarro; Augustine M K Choi; Kenneth B Christopher Journal: JPEN J Parenter Enteral Nutr Date: 2016-07-19 Impact factor: 4.016
Authors: Camila Hirotsu; Sergio Tufik; Camila Guindalini; Diego R Mazzotti; Lia R Bittencourt; Monica L Andersen Journal: PLoS One Date: 2013-06-24 Impact factor: 3.240
Authors: Maria T Kuipers; Hamid Aslami; Alexander P J Vlaar; Nicole P Juffermans; Anita M Tuip-de Boer; Maria A Hegeman; Geartsje Jongsma; Joris J T H Roelofs; Tom van der Poll; Marcus J Schultz; Catharina W Wieland Journal: PLoS One Date: 2012-11-30 Impact factor: 3.240