| Literature DB >> 16439115 |
José M Padrón1, Pedro O Miranda, Juan I Padrón, Víctor S Martín.
Abstract
A series of beta'-hydroxy-alpha,beta-unsaturated ketones were prepared by means of an iron(III) catalyzed domino process. The in vitro antiproliferative activities were examined in the human solid tumor cell lines A2780, SW1573, and WiDr. The results showed that beta'-hydroxy-alpha,beta-unsaturated ketones were more potent than alpha,beta-unsaturated ketones. The best activity profiles were obtained for the derivatives bearing cyclic or branched substituents on the side chains.Entities:
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Year: 2006 PMID： 16439115 DOI： 10.1016/j.bmcl.2006.01.023
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823