Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 The analgesic activity of paracetamol is prevented by the blockade of cannabinoid CB1 receptors.

Literature DB >> 16438952

The analgesic activity of paracetamol is prevented by the blockade of cannabinoid CB1 receptors.

Alessandra Ottani¹, Sheila Leone, Maurizio Sandrini, Anna Ferrari, Alfio Bertolini.

Abstract

The mechanism of the analgesic activity of paracetamol (acetaminophen), one of the most widely used drugs for the treatment of pain, is still not clear. Here we show that in rats, using the hot plate test, the analgesic effect of paracetamol is prevented by two antagonists at cannabinoid CB1 receptors (AM281 and SR141716A) at doses that prevent the analgesic activity of the cannabinoid CB1 agonist HU210. Our present results suggest that paracetamol-induced antinociception involves the cannabinoid system.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 2006 PMID： 16438952 DOI： 10.1016/j.ejphar.2005.12.015

Source DB: PubMed Journal: Eur J Pharmacol ISSN： 0014-2999 Impact factor: 4.432

Keyword Cloud
Cited

64 in total

1. Acetaminophen inhibits status epilepticus in cultured hippocampal neurons.

Authors: Laxmikant S Deshpande; Robert J DeLorenzo
Journal: Neuroreport Date: 2011-01-05 Impact factor: 1.837

Review 2. Paracetamol: new vistas of an old drug.

Authors: Alfio Bertolini; Anna Ferrari; Alessandra Ottani; Simona Guerzoni; Raffaella Tacchi; Sheila Leone
Journal: CNS Drug Rev Date: 2006 Fall-Winter

Review 3. The case for the development of novel analgesic agents targeting both fatty acid amide hydrolase and either cyclooxygenase or TRPV1.

Authors: C J Fowler; P S Naidu; A Lichtman; V Onnis
Journal: Br J Pharmacol Date: 2009-02 Impact factor: 8.739

4. Differential hepatoprotective role of the cannabinoid CB₁ and CB₂ receptors in paracetamol-induced liver injury.

Authors: Patricia Rivera; Antonio Vargas; Antoni Pastor; Anna Boronat; Antonio Jesús López-Gambero; Laura Sánchez-Marín; Dina Medina-Vera; Antonia Serrano; Francisco Javier Pavón; Rafael de la Torre; Ekaitz Agirregoitia; María Isabel Lucena; Fernando Rodríguez de Fonseca; Juan Decara; Juan Suárez
Journal: Br J Pharmacol Date: 2020-04-15 Impact factor: 8.739

5. Acute over-the-counter pharmacological intervention does not adversely affect behavioral outcome following diffuse traumatic brain injury in the mouse.

Authors: Jordan L Harrison; Rachel K Rowe; Bruce F O'Hara; P David Adelson; Jonathan Lifshitz
Journal: Exp Brain Res Date: 2014-04-24 Impact factor: 1.972

6. [Pediatric perioperative systemic pain therapy: Austrian interdisciplinary recommendations on pediatric perioperative pain management].

Authors: B Messerer; G Grögl; W Stromer; W Jaksch
Journal: Schmerz Date: 2014-02 Impact factor: 1.107

The analgesic activity of paracetamol is prevented by the blockade of cannabinoid CB1 receptors.

1. Acetaminophen inhibits status epilepticus in cultured hippocampal neurons.

Review 2. Paracetamol: new vistas of an old drug.

Review 3. The case for the development of novel analgesic agents targeting both fatty acid amide hydrolase and either cyclooxygenase or TRPV1.

4. Differential hepatoprotective role of the cannabinoid CB₁ and CB₂ receptors in paracetamol-induced liver injury.

5. Acute over-the-counter pharmacological intervention does not adversely affect behavioral outcome following diffuse traumatic brain injury in the mouse.

6. [Pediatric perioperative systemic pain therapy: Austrian interdisciplinary recommendations on pediatric perioperative pain management].

7. The analgesic efficacy of intra-articular acetaminophen in an experimental model of carrageenan-induced arthritis.

Review 8. Mechanisms of non-opioid analgesics beyond cyclooxygenase enzyme inhibition.

9. Different mechanisms underlie the analgesic actions of paracetamol and dipyrone in a rat model of inflammatory pain.

Review 10. The pharmacology of the cannabinoid system--a question of efficacy and selectivity.

The analgesic activity of paracetamol is prevented by the blockade of cannabinoid CB1 receptors.

1. Acetaminophen inhibits status epilepticus in cultured hippocampal neurons.

Review 2. Paracetamol: new vistas of an old drug.

Review 3. The case for the development of novel analgesic agents targeting both fatty acid amide hydrolase and either cyclooxygenase or TRPV1.

4. Differential hepatoprotective role of the cannabinoid CB1 and CB2 receptors in paracetamol-induced liver injury.

5. Acute over-the-counter pharmacological intervention does not adversely affect behavioral outcome following diffuse traumatic brain injury in the mouse.

6. [Pediatric perioperative systemic pain therapy: Austrian interdisciplinary recommendations on pediatric perioperative pain management].

7. The analgesic efficacy of intra-articular acetaminophen in an experimental model of carrageenan-induced arthritis.

Review 8. Mechanisms of non-opioid analgesics beyond cyclooxygenase enzyme inhibition.

9. Different mechanisms underlie the analgesic actions of paracetamol and dipyrone in a rat model of inflammatory pain.

Review 10. The pharmacology of the cannabinoid system--a question of efficacy and selectivity.

4. Differential hepatoprotective role of the cannabinoid CB₁ and CB₂ receptors in paracetamol-induced liver injury.