BACKGROUND: Prior research indicates that conduct disorder (CD) is associated with a range of co-morbid mental disorders. However, the actual prevalence, subtypes and patterns of co-morbidity of DSM-IV-defined CD in the general US population remains unknown. METHOD: Retrospective assessment of CD and other DSM-IV disorders was conducted using fully structured diagnostic interviews among a nationally representative sample of respondents (n=3199) in the National Comorbidity Survey Replication (NCS-R). RESULTS: The estimated lifetime prevalence of CD in the US is 9.5% (12.0% among males and 7.1% among females), with a median age-of-onset of 11.6 (0.2) years. Latent class analysis (LCA) identified five CD subtypes characterized by rule violations, deceit/theft, aggression, severe covert behaviors, and pervasive CD symptoms. A dose-response relationship was revealed between CD subtype severity and risk of subsequent disorders. Results also indicated that CD typically precedes mood and substance use disorders, but most often occurs after impulse control and anxiety disorders. Although both active and remitted CD is associated with increased risk of the subsequent first onset of other mental disorders, remitted CD is associated with significantly lower risk of subsequent disorders. CONCLUSIONS: CD is prevalent and heterogeneous in the US population, and more severe subtypes and the presence of active CD are associated with higher risk of co-morbid disorders. Future prospective studies using general population samples will further inform the nature and course of this disorder.
BACKGROUND: Prior research indicates that conduct disorder (CD) is associated with a range of co-morbid mental disorders. However, the actual prevalence, subtypes and patterns of co-morbidity of DSM-IV-defined CD in the general US population remains unknown. METHOD: Retrospective assessment of CD and other DSM-IV disorders was conducted using fully structured diagnostic interviews among a nationally representative sample of respondents (n=3199) in the National Comorbidity Survey Replication (NCS-R). RESULTS: The estimated lifetime prevalence of CD in the US is 9.5% (12.0% among males and 7.1% among females), with a median age-of-onset of 11.6 (0.2) years. Latent class analysis (LCA) identified five CD subtypes characterized by rule violations, deceit/theft, aggression, severe covert behaviors, and pervasive CD symptoms. A dose-response relationship was revealed between CD subtype severity and risk of subsequent disorders. Results also indicated that CD typically precedes mood and substance use disorders, but most often occurs after impulse control and anxiety disorders. Although both active and remitted CD is associated with increased risk of the subsequent first onset of other mental disorders, remitted CD is associated with significantly lower risk of subsequent disorders. CONCLUSIONS: CD is prevalent and heterogeneous in the US population, and more severe subtypes and the presence of active CD are associated with higher risk of co-morbid disorders. Future prospective studies using general population samples will further inform the nature and course of this disorder.
Authors: Ronald C Kessler; Lenard A Adler; Russell Barkley; Joseph Biederman; C Keith Conners; Stephen V Faraone; Laurence L Greenhill; Savina Jaeger; Kristina Secnik; Thomas Spencer; T Bedirhan Ustün; Alan M Zaslavsky Journal: Biol Psychiatry Date: 2005-06-01 Impact factor: 13.382
Authors: Ronald C Kessler; Patricia Berglund; Olga Demler; Robert Jin; Kathleen R Merikangas; Ellen E Walters Journal: Arch Gen Psychiatry Date: 2005-06
Authors: Joshua Breslau; Guilherme Borges; Naomi Saito; Daniel J Tancredi; Corina Benjet; Ladson Hinton; Kenneth S Kendler; Richard Kravitz; William Vega; Sergio Aguilar-Gaxiola; Maria Elena Medina-Mora Journal: Arch Gen Psychiatry Date: 2011-12
Authors: Manish S Dalwani; Jason R Tregellas; Jessica R Andrews-Hanna; Susan K Mikulich-Gilbertson; Kristen M Raymond; Marie T Banich; Thomas J Crowley; Joseph T Sakai Journal: Drug Alcohol Depend Date: 2013-10-24 Impact factor: 4.492
Authors: H Christiansen; W Chen; R D Oades; P Asherson; E A Taylor; J Lasky-Su; K Zhou; T Banaschewski; C Buschgens; B Franke; I Gabriels; I Manor; R Marco; U C Müller; A Mulligan; L Psychogiou; N N J Rommelse; H Uebel; J Buitelaar; R P Ebstein; J Eisenberg; M Gill; A Miranda; F Mulas; H Roeyers; A Rothenberger; J A Sergeant; E J S Sonuga-Barke; H-C Steinhausen; M Thompson; S V Faraone Journal: J Neural Transm (Vienna) Date: 2008-01-16 Impact factor: 3.575