Literature DB >> 16438

Effect of hypercapnia and hypocapnia on tryptophan and tyrosine hydroxylation in rat brain.

A Carlsson, T Holmin, M Lindqvist, B K Siesjö.   

Abstract

The effects of induced hypo- and hypercapnia upon the rate of hydroxylation of tryptophan and tyrosine in the rat brain were studied by measuring the accumulation of 5-HTP and DOPA following administration of the aromatic L-aminoacid decarboxylase inhibitor 3-hydroxybenzylhydrazine HCl (NSD 1015). The results suggest that the hydroxylation of tryptophan varies directly with the tissue Po2. On the other hand, the hydroxylation of tyrosine did not show a simple relationship to Po2 but appeared to be influenced by pH changes.

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Year:  1977        PMID： 16438     DOI： 10.1111/j.1748-1716.1977.tb10404.x

Source DB:  PubMed          Journal:  Acta Physiol Scand        ISSN： 0001-6772


  2 in total

1.  The effect of CO2 on monoamine metabolism in rat brain.

Authors:  J Garcia de Yebenes Prous; A Carlsson; M A Mena Gomez
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1977-12       Impact factor: 3.000

2.  GRK3 deficiency elicits brain immune activation and psychosis.

Authors:  Carl M Sellgren; Sophie Imbeault; Markus K Larsson; Alfredo Oliveros; Ida A K Nilsson; Simone Codeluppi; Funda Orhan; Maria Bhat; Maximilian Tufvesson-Alm; Jessica Gracias; Magdalena E Kegel; Yiran Zheng; Anthi Faka; Marie Svedberg; Susan B Powell; Sorana Caldwell; Mary E Kamenski; Marquis P Vawter; Anton Schulmann; Michel Goiny; Camilla I Svensson; Tomas Hökfelt; Martin Schalling; Lilly Schwieler; Simon Cervenka; Doo-Sup Choi; Mikael Landén; Göran Engberg; Sophie Erhardt
Journal:  Mol Psychiatry       Date:  2021-05-12       Impact factor: 15.992
  2 in total

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