Literature DB >> 16437676

Delayed development of hepatocellular carcinoma during long-term follow-up after eradication of hepatitis C virus by interferon therapy.

Yukiko Ito1, Natsuyo Yamamoto, Ryo Nakata, Yoshihisa Kato, Masashi Iori, Keisuke Sakai, Tamiko Takemura, Ryosuke Tateishi, Haruhiko Yoshida, Takao Kawabe, Masao Omata.   

Abstract

A 42-year-old Japanese man with liver cirrhosis by hepatitis C virus (HCV) had successful interferon therapy in May 1991. Since then, serum HCV-RNA and liver function tests had been negative. He had continued to drink more than 100 g/d of alcohol as before. In June 2003, a 5-cm tumor was found in the posterior segment of the liver. The tumor was curatively resected and the surgical specimen showed a well-differentiated hepatocellular carcinoma (HCC). Non-cancerous lesions of the liver revealed fibrosis at stage F3 with minimal to mild inflammation of grade A1. Heavy drinking may retard the dissolution of fibrosis and accelerate HCC development in patients with sustained virological response.

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Year:  2005        PMID： 16437676      PMCID： PMC4725085          DOI： 10.3748/wjg.v11.i45.7218

Source DB:  PubMed          Journal:  World J Gastroenterol        ISSN： 1007-9327            Impact factor:   5.742


  21 in total

1.  Prevalence of antibodies to hepatitis C virus in Spanish patients with hepatocellular carcinoma and hepatic cirrhosis.

Authors:  J Bruix; J M Barrera; X Calvet; G Ercilla; J Costa; J M Sanchez-Tapias; M Ventura; M Vall; M Bruguera; C Bru
Journal:  Lancet       Date:  1989-10-28       Impact factor: 79.321

2.  Combination of "low-dose" ribavirin and interferon alfa-2a therapy followed by interferon alfa-2a monotherapy in chronic HCV-infected non-responders and relapsers after interferon alfa-2a monotherapy.

Authors:  P Wietzkebetaraun; V Meier; F Braun; G Ramadori
Journal:  World J Gastroenterol       Date:  2001-04       Impact factor: 5.742

3.  Treatment of chronic hepatitis C with recombinant interferon alfa. A multicenter randomized, controlled trial.

Authors:  G L Davis; L A Balart; E R Schiff; K Lindsay; H C Bodenheimer; R P Perrillo; W Carey; I M Jacobson; J Payne; J L Dienstag
Journal:  N Engl J Med       Date:  1989-11-30       Impact factor: 91.245

4.  Recombinant interferon alfa therapy for chronic hepatitis C. A randomized, double-blind, placebo-controlled trial.

Authors:  A M Di Bisceglie; P Martin; C Kassianides; M Lisker-Melman; L Murray; J Waggoner; Z Goodman; S M Banks; J H Hoofnagle
Journal:  N Engl J Med       Date:  1989-11-30       Impact factor: 91.245

5.  Predictors of the efficacy of interferon therapy for patients with chronic hepatitis C before and during therapy: how does this modify the treatment course?

Authors:  Y Shiratori; M Omata
Journal:  J Gastroenterol Hepatol       Date:  2000-05       Impact factor: 4.029

6.  Development of small hepatocellular carcinoma in a patient with chronic hepatitis C after 77 months of a sustained and complete response to interferon therapy.

Authors:  Takahiro Yamaura; Akihiro Matsumoto; Akinori Rokuhara; Tetuya Ichijo; Ehji Tanaka; Kazuhiro Hanazaki; Shoji Kajikawa; Kendo Kiyosawa
Journal:  J Gastroenterol Hepatol       Date:  2002-11       Impact factor: 4.029

7.  Incidence of hepatocellular carcinoma in chronic hepatitis B and C: a prospective study of 251 patients.

Authors:  S Takano; O Yokosuka; F Imazeki; M Tagawa; M Omata
Journal:  Hepatology       Date:  1995-03       Impact factor: 17.425

8.  A multivariate analysis of risk factors for hepatocellular carcinogenesis: a prospective observation of 795 patients with viral and alcoholic cirrhosis.

Authors:  K Ikeda; S Saitoh; I Koida; Y Arase; A Tsubota; K Chayama; H Kumada; M Kawanishi
Journal:  Hepatology       Date:  1993-07       Impact factor: 17.425

9.  The role of chronic viral hepatitis in hepatocellular carcinoma in the United States.

Authors:  A M Di Bisceglie; S E Order; J L Klein; J G Waggoner; M H Sjogren; G Kuo; M Houghton; Q L Choo; J H Hoofnagle
Journal:  Am J Gastroenterol       Date:  1991-03       Impact factor: 10.864

10.  Interferon plus ribavirin and interferon alone in preventing hepatocellular carcinoma: a prospective study on patients with HCV related cirrhosis.

Authors:  Francesco Azzaroli; Esterita Accogli; Giovanni Nigro; Davide Trere; Silvia Giovanelli; Anna Miracolo; Francesca Lodato; Marco Montagnani; Mariarosa Tamé; Antonio Colecchia; Constance Mwangemi; Davide Festi; Enrico Roda; Massimo Derenzini; Giuseppe Mazzella
Journal:  World J Gastroenterol       Date:  2004-11-01       Impact factor: 5.742
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  6 in total

Review 1.  Review.

Authors:  Eric R Kallwitz
Journal:  Gastroenterol Hepatol (N Y)       Date:  2006-08

2.  A case of intrahepatic cholangiocarcinoma detected after successful interferon therapy for chronic hepatitis C.

Authors:  Hiroji Shinkawa; Seikan Hai; Hiromu Tanaka; Shigekazu Takemura; Kazuki Ohba; Takahiro Uenishi; Shintaro Kodai; Yorihisa Urata; Kazuhisa Kaneda; Masayuki Sakae; Kenichi Wakasa; Shoji Kubo
Journal:  Clin J Gastroenterol       Date:  2009-12-03

3.  Development of a hepatocellular carcinoma in a chronic hepatitis C patient 18 years after achieving a sustained virological response to interferon therapy: case report and literature review.

Authors:  Masaya Saito; Yasushi Seo; Yoshihiko Yano; Akira Miki; Yukiko Morinaga; Tomoo Itoh; Masaru Yoshida; Takeshi Azuma
Journal:  Clin J Gastroenterol       Date:  2012-02-18

4.  Hepatocarcinogenesis in chronic hepatitis C patients achieving a sustained virological response to interferon: significance of lifelong periodic cancer screening for improving outcomes.

Authors:  Naoki Yamashita; Aritsune Ohho; Akihiro Yamasaki; Miho Kurokawa; Kazuhiro Kotoh; Eiji Kajiwara
Journal:  J Gastroenterol       Date:  2013-12-08       Impact factor: 7.527

Review 5.  Occurrence of hepatocellular carcinoma 24 years after successful interferon therapy in a patient with chronic hepatitis C: a case report.

Authors:  Yuichi Yoshida; Miki Yonezawa; Takuya Okamoto; Yudai Fujiwara; Akiko Suzuki; Yuji Suzuki; Kei Endo; Keisuke Kakisaka; Takayoshi Oikawa; Hidekatsu Kuroda; Akio Miyasaka; Yasuhiro Takikawa
Journal:  Clin J Gastroenterol       Date:  2018-10-19

6.  Hepatocellular Carcinoma 11 and a Half Years after the Resolution of Chronic Hepatitis C Virus Infection Successfully Treated with Interferon.

Authors:  Naoki Hotta; Minoru Ayada; Akihiko Okumura; Tetsuya Ishikawa; Ken Sato; Tomohiko Oohashi; Yasutaka Hijikata; Shinichi Kakumu
Journal:  Case Rep Gastroenterol       Date:  2009-07-03
  6 in total

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