Literature DB >> 16437168

Metal complexes in medicinal chemistry: new vistas and challenges in drug design.

Katherine H Thompson1, Chris Orvig.   

Abstract

An overview is presented of selected metal-based pharmaceuticals, either diagnostic or therapeutic, with emphasis on specific attributes and in vivo interactions of these compounds relevant to their use in medicinal applications. Both the advantages and the challenges of this approach are outlined, with possibilities for future developments accentuated.

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Year:  2005        PMID： 16437168     DOI： 10.1039/b513476e

Source DB:  PubMed          Journal:  Dalton Trans        ISSN： 1477-9226            Impact factor:   4.390


  25 in total

1.  Synthesis, metal ion binding, and biological evaluation of new anticancer 2-(2'-hydroxyphenyl)benzoxazole analogs of UK-1.

Authors:  Mireya L McKee; Sean M Kerwin
Journal:  Bioorg Med Chem       Date:  2007-11-12       Impact factor: 3.641

2.  Spectroscopic elucidation of the inhibitory mechanism of Cys2His2 zinc finger transcription factors by cobalt(III) Schiff base complexes.

Authors:  Marie C Heffern; Josh W Kurutz; Thomas J Meade
Journal:  Chemistry       Date:  2013-11-06       Impact factor: 5.236

Review 3.  Application of metal coordination chemistry to explore and manipulate cell biology.

Authors:  Kathryn L Haas; Katherine J Franz
Journal:  Chem Rev       Date:  2009-10       Impact factor: 60.622

4.  Structural analysis and biological functionalities of iron(III)- and manganese(III)-thiosemicarbazone complexes: in vitro anti-proliferative activity on human cancer cells, DNA binding and cleavage studies.

Authors:  Büşra Kaya; Zehra Kübra Yılmaz; Onur Şahin; Belma Aslim; Ümmügülsüm Tükenmez; Bahri Ülküseven
Journal:  J Biol Inorg Chem       Date:  2019-03-20       Impact factor: 3.358

5.  Theoretical and experimental studies on three new coordination complexes of Co(II), Ni(II), and Cu(II) with 2,4-dichloro-6-{(E)-[(5-chloro-2 sulfanylphenyl)imino]methyl}phenol Schiff base ligand.

Authors:  Brajendra S Kusmariya; A P Mishra
Journal:  J Mol Model       Date:  2015-10-05       Impact factor: 1.810

6.  Recent perspectives into biochemistry of decavanadate.

Authors:  Manuel Aureliano
Journal:  World J Biol Chem       Date:  2011-10-26

7.  In vitro and in vivo antitumor effects of the VO-chrysin complex on a new three-dimensional osteosarcoma spheroids model and a xenograft tumor in mice.

Authors:  Ignacio E León; Juan F Cadavid-Vargas; Agustina Resasco; Fabricio Maschi; Miguel A Ayala; Cecilia Carbone; Susana B Etcheverry
Journal:  J Biol Inorg Chem       Date:  2016-10-01       Impact factor: 3.358

8.  (Methoxo-κO)oxidobis(quinolin-8-olato-κN,O)vanadium(V).

Authors:  Zhenghua Guo; Lianzhi Li; Chengyuan Wang; Tao Xu; Jinghong Li
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2009-08-15

9.  Metalloprobes: synthesis, characterization, and potency of a novel gallium(III) complex in human epidermal carcinoma cells.

Authors:  Scott E Harpstrite; Julie L Prior; Nigam P Rath; Vijay Sharma
Journal:  J Inorg Biochem       Date:  2007-05-08       Impact factor: 4.155

10.  Antidiabetic Bis-Maltolato-OxoVanadium(IV): conversion of inactive trans- to bioactive cis-BMOV for possible binding to target PTP-1B.

Authors:  Thomas Scior; Hans-Georg Mack; José Antonio Guevara García; Wolfhard Koch
Journal:  Drug Des Devel Ther       Date:  2009-02-06       Impact factor: 4.162
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