Literature DB >> 16435854

A putative precursor of isomalabaricane triterpenoids from lanosterol synthase mutants.

Silvia Lodeiro1, William K Wilson, Hui Shan, Seiichi P T Matsuda.   

Abstract

[reaction: see text]. Known lanosterol synthase mutants produce monocyclic or tetracyclic byproducts from oxidosqualene. We describe Erg7 Tyr510 mutants that cause partial substrate misfolding and generate a tricyclic byproduct. This novel triterpene, (13alphaH)-isomalabarica-14(27),17E,21-trien-3beta-ol, is the likely biosynthetic precursor of isomalabaricane triterpenoids in sponges. The results suggest the facile evolution of protective triterpenoids in sessile animals.

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Year:  2006        PMID： 16435854     DOI： 10.1021/ol052725j

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


  3 in total

1.  Subverting Hedgehog Protein Autoprocessing by Chemical Induction of Paracatalysis.

Authors:  Carl J Smith; Andrew G Wagner; Robert T Stagnitta; Zihan Xu; John L Pezzullo; José-Luis Giner; Jian Xie; Douglas F Covey; Chunyu Wang; Brian P Callahan
Journal:  Biochemistry       Date:  2020-02-04       Impact factor: 3.162

2.  Synthesis of arborane triterpenols by a bacterial oxidosqualene cyclase.

Authors:  Amy B Banta; Jeremy H Wei; Clare C C Gill; José-Luis Giner; Paula V Welander
Journal:  Proc Natl Acad Sci U S A       Date:  2016-12-27       Impact factor: 11.205

Review 3.  Malabaricane and Isomalabaricane Triterpenoids, Including Their Glycoconjugated Forms.

Authors:  Valentin A Stonik; Sophia A Kolesnikova
Journal:  Mar Drugs       Date:  2021-06-05       Impact factor: 5.118
  3 in total

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