| Literature DB >> 16434666 |
S M Hersch1, S Gevorkian, K Marder, C Moskowitz, A Feigin, M Cox, P Como, C Zimmerman, M Lin, L Zhang, A M Ulug, M F Beal, W Matson, M Bogdanov, E Ebbel, A Zaleta, Y Kaneko, B Jenkins, N Hevelone, H Zhang, H Yu, D Schoenfeld, R Ferrante, H D Rosas.
Abstract
In a randomized, double-blind, placebo-controlled study in 64 subjects with Huntington disease (HD), 8 g/day of creatine administered for 16 weeks was well tolerated and safe. Serum and brain creatine concentrations increased in the creatine-treated group and returned to baseline after washout. Serum 8-hydroxy-2'-deoxyguanosine (8OH2'dG) levels, an indicator of oxidative injury to DNA, were markedly elevated in HD and reduced by creatine treatment.Entities:
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Year: 2006 PMID： 16434666 DOI： 10.1212/01.wnl.0000194318.74946.b6
Source DB: PubMed Journal: Neurology ISSN： 0028-3878 Impact factor: 9.910