| Literature DB >> 16434203 |
Seong Jun Park1, Sung Jun Park, Min Joo Lee, Hyewhon Rhim, Yoonjee Kim, Jung-Ha Lee, Bong Young Chung, Jae Yeol Lee.
Abstract
For the novel, potent, and selective T-type Ca2+ channel blockers, a series of sulfonamido-containing 3,4-dihydroquinazoline derivatives were prepared and evaluated for their blocking actions on T- and N-type Ca2+ channels. Among them, 9c (KYS05064, IC50 = 0.96 +/- 0.22 microM) was found to be as potent as Mibefradil and also showed the highest selectivity for T-type Ca2+ channel with no effect on N-type Ca2+ channel.Entities:
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Year: 2006 PMID： 16434203 DOI： 10.1016/j.bmc.2006.01.005
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641