Literature DB >> 16433023

HuR, an RNA-binding protein, involved in the control of cellular differentiation.

Joy Cherry1, Vesna Karschner, Heath Jones, Phillip H Pekala.   

Abstract

HuR is an RNA-binding protein that resides predominantly in the nucleus but shuttles to the cytosol carrying mRNAs containing a uridylate-rich region in the 3'untranslated region. Data suggest that HuR is involved in the control of the differentiation process through a tightly regulated selection of mRNAs to be shuttled to the cytosol for translation. In this review, the function of HuR in the differentiation process of preadipocytes is examined in the context of specific mRNAs selected by HuR for translocation to the cytosol.

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Year:  2006        PMID： 16433023

Source DB:  PubMed          Journal:  In Vivo        ISSN： 0258-851X            Impact factor:   2.155


  27 in total

1.  HuR binds to a single site on the C/EBPbeta mRNA of 3T3-L1 adipocytes.

Authors:  Heath Jones; Melinda Carver; Phillip H Pekala
Journal:  Biochem Biophys Res Commun       Date:  2007-02-02       Impact factor: 3.575

2.  miR-519 reduces cell proliferation by lowering RNA-binding protein HuR levels.

Authors:  Kotb Abdelmohsen; Subramanya Srikantan; Yuki Kuwano; Myriam Gorospe
Journal:  Proc Natl Acad Sci U S A       Date:  2008-12-16       Impact factor: 11.205

3.  Hu antigen R and tristetraprolin: counter-regulators of rat apical sodium-dependent bile acid transporter by way of effects on messenger RNA stability.

Authors:  Frank Chen; Ann-Bin Shyu; Benjamin L Shneider
Journal:  Hepatology       Date:  2011-08-09       Impact factor: 17.425

4.  Insights from the HuR-interacting transcriptome: ncRNAs, ubiquitin pathways, and patterns of secondary structure dependent RNA interactions.

Authors:  Georges St Laurent; Dmitry Shtokalo; Mohammad Heydarian; Andrey Palyanov; Dmitry Babiy; Jianhua Zhou; Ajit Kumar; Silvio Urcuqui-Inchima
Journal:  Mol Genet Genomics       Date:  2012-10-04       Impact factor: 3.291

5.  The C-terminal RNA binding motif of HuR is a multi-functional domain leading to HuR oligomerization and binding to U-rich RNA targets.

Authors:  Rafael M Scheiba; Alain Ibáñez de Opakua; Antonio Díaz-Quintana; Isabel Cruz-Gallardo; Luis A Martínez-Cruz; María L Martínez-Chantar; Francisco J Blanco; Irene Díaz-Moreno
Journal:  RNA Biol       Date:  2014       Impact factor: 4.652

6.  HuR function and translational state analysis following global brain ischemia and reperfusion.

Authors:  Jeffrey J Szymanski; Haihui Wang; Jill T Jamison; Donald J DeGracia
Journal:  Transl Stroke Res       Date:  2013-08-02       Impact factor: 6.829

7.  Persistent redistribution of poly-adenylated mRNAs correlates with translation arrest and cell death following global brain ischemia and reperfusion.

Authors:  J T Jamison; F Kayali; J Rudolph; M Marshall; S R Kimball; D J DeGracia
Journal:  Neuroscience       Date:  2008-04-01       Impact factor: 3.590

8.  Cold-inducible RNA-binding protein contributes to human antigen R and cyclin E1 deregulation in breast cancer.

Authors:  Xun Guo; Yuehan Wu; Rebecca S Hartley
Journal:  Mol Carcinog       Date:  2010-02       Impact factor: 4.784

9.  Promotion of exon 6 inclusion in HuD pre-mRNA by Hu protein family members.

Authors:  Huiwen Wang; Jill Molfenter; Hui Zhu; Hua Lou
Journal:  Nucleic Acids Res       Date:  2010-02-16       Impact factor: 16.971

Review 10.  Diverse molecular functions of Hu proteins.

Authors:  M N Hinman; H Lou
Journal:  Cell Mol Life Sci       Date:  2008-10       Impact factor: 9.261
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