Literature DB >> 1643102

Glucocorticoids inhibit TNF alpha-induced cytosolic phospholipase A2 activity.

M Goppelt-Struebe1, W Rehfeldt.   

Abstract

The cytosolic phospholipase A2 (PLA2) was characterized in the human epithelial carcinoma cell line HEp-2 by its apparent molecular mass (about 80 kDa); its in vitro activation by micromolar concentrations of calcium; and its calcium-dependent association with cellular membranes. The activity of this enzyme was induced by an overnight incubation with tumor necrosis factor alpha (TNF alpha). Glucocorticoids only moderately reduced PLA2 activity in control cells, but completely inhibited the TNF alpha-induced increase in the activity of the high-molecular-weight cytosolic PLA2.

Entities:  

Mesh：

Substances：

Year:  1992        PMID： 1643102     DOI： 10.1016/0005-2760(92)90273-x

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  7 in total

1.  Regulation of arachidonic acid, eicosanoid, and phospholipase A2 levels in murine mast cells by recombinant stem cell factor.

Authors:  A N Fonteh; J M Samet; F H Chilton
Journal:  J Clin Invest       Date:  1995-09       Impact factor: 14.808

2.  Cytosolic phospholipase A2 from human monocytic cells: characterization of substrate specificity and Ca(2+)-dependent membrane association.

Authors:  W Rehfeldt; K Resch; M Goppelt-Struebe
Journal:  Biochem J       Date:  1993-07-01       Impact factor: 3.857

3.  Cytokine-stimulated secretion of group II phospholipase A2 by rat mesangial cells. Its contribution to arachidonic acid release and prostaglandin synthesis by cultured rat glomerular cells.

Authors:  J Pfeilschifter; C Schalkwijk; V A Briner; H van den Bosch
Journal:  J Clin Invest       Date:  1993-11       Impact factor: 14.808

4.  Are events after endotoxemia related to circulating phospholipase A2?

Authors:  A A Santos; J L Browning; M R Scheltinga; E A Lynch; E F Brown; P Lawton; E Chambers; I Dougas; C D Benjamin; C A Dinarello
Journal:  Ann Surg       Date:  1994-02       Impact factor: 12.969

5.  Dexamethasone down-regulates the 85 kDa phospholipase A2 in mouse macrophages and suppresses its activation.

Authors:  K Gewert; R Sundler
Journal:  Biochem J       Date:  1995-04-15       Impact factor: 3.857

6.  Identification of a 27 bp 5'-flanking region element responsible for the low level constitutive expression of the human cytosolic phospholipase A2 gene.

Authors:  A Miyashita; R G Crystal; J G Hay
Journal:  Nucleic Acids Res       Date:  1995-01-25       Impact factor: 16.971

7.  Glucocorticoids as cytokine inhibitors: role in neuroendocrine control and therapy of inflammatory diseases.

Authors:  G Fantuzzi; P Ghezzi
Journal:  Mediators Inflamm       Date:  1993       Impact factor: 4.711
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.