Literature DB >> 16426703

Wound repair and proliferation of bronchial epithelial cells enhanced by bombesin receptor subtype 3 activation.

Yu-Rong Tan1, Ming-Ming Qi, Xiao-Qun Qin, Yang Xiang, Xiang Li, Yue Wang, Fei Qu, Hui-Jun Liu, Jian-Song Zhang.   

Abstract

The present study was designed to investigate the role of bombesin receptor subtype 3 (BRS-3) in airway wound repair. The results showed that: (1) There was few expression of BRS-3 mRNA in the control group. In contrast, the expression of BRS-3 mRNA was gradually increased in the early 2 days, and peaked on the fourth day, and then decreased in the ozone-stressed AHR animal. BRS-3 mRNA was distributed in the ciliated columnar epithelium, monolayer columnar epithelium cells, scattered mesenchymal cells and Type II alveolar cells; (2) The wound repair and proliferation of bronchial epithelial cells (BECs) were accelerated in a concentration-dependent manner by BRS-3 activation with P3513, which could be inhibited by PKA inhibitor H89. The study demostrated that activation of BRS-3 may play an important role in wound repair of AHR.

Entities:  

Mesh：

Substances：

Year:  2006        PMID： 16426703     DOI： 10.1016/j.peptides.2005.12.012

Source DB:  PubMed          Journal:  Peptides        ISSN： 0196-9781            Impact factor:   3.750


  19 in total

1.  Pharmacokinetics and pharmacodynamics of MK-5046, a bombesin receptor subtype-3 (BRS-3) agonist, in healthy patients.

Authors:  Marc L Reitman; Victor Dishy; Allison Moreau; William S Denney; Chengcheng Liu; Walter K Kraft; Alex V Mejia; Mark A Matson; S Aubrey Stoch; John A Wagner; Eseng Lai
Journal:  J Clin Pharmacol       Date:  2011-12-12       Impact factor: 3.126

2.  Pharmacology of putative selective hBRS-3 receptor agonists for human bombesin receptors (BnR): affinities, potencies and selectivity in multiple native and BnR transfected cells.

Authors:  Veronica Sancho; Terry W Moody; Samuel A Mantey; Alessia Di Florio; Hirotsugu Uehara; David H Coy; Robert T Jensen
Journal:  Peptides       Date:  2010-05-12       Impact factor: 3.750

3.  Wound repair and anti-oxidative capacity is regulated by ITGB4 in airway epithelial cells.

Authors:  Chi Liu; Hui-jun Liu; Yang Xiang; Yu-rong Tan; Xiao-lin Zhu; Xiao-qun Qin
Journal:  Mol Cell Biochem       Date:  2010-04-03       Impact factor: 3.396

4.  Receptor-specific crosstalk between prostanoid E receptor 3 and bombesin receptor subtype 3.

Authors:  Yan Zhang; Yanfang Liu; Lehao Wu; Chao Fan; Zhiwei Wang; Xiuli Zhang; Amal Alachkar; Xinmiao Liang; Olivier Civelli
Journal:  FASEB J       Date:  2018-01-22       Impact factor: 5.191

5.  Dimethylarginine dimethylaminohydrolase (DDAH) overexpression enhances wound repair in airway epithelial cells exposed to agricultural organic dust.

Authors:  Deepak Chandra; Jill A Poole; Kristina L Bailey; Elizabeth Staab; Jenea M Sweeter; Jane M DeVasure; Debra J Romberger; Todd A Wyatt
Journal:  Inhal Toxicol       Date:  2018-05-25       Impact factor: 2.724

6.  Pharmacology and selectivity of various natural and synthetic bombesin related peptide agonists for human and rat bombesin receptors differs.

Authors:  Hirotsugu Uehara; Nieves González; Veronica Sancho; Samuel A Mantey; Bernardo Nuche-Berenguer; Tapas Pradhan; David H Coy; Robert T Jensen
Journal:  Peptides       Date:  2011-06-28       Impact factor: 3.750

7.  Elevated gastrin-releasing peptide receptor mRNA expression in buccal mucosa: association with head and neck squamous cell carcinoma.

Authors:  Ann Marie Egloff; Xuwan Liu; Autumn L Gaither Davis; Brian K Trevelline; Marike Vuga; Jill M Siegfried; Jennifer R Grandis
Journal:  Head Neck       Date:  2012-03-20       Impact factor: 3.147

8.  A selective human bombesin receptor subtype-3 peptide agonist mediates CREB phosphorylation and transactivation.

Authors:  Xiaoqun Qin; Xiangping Qu; David Coy; H Christian Weber
Journal:  J Mol Neurosci       Date:  2011-11-30       Impact factor: 3.444

9.  Bombesin receptor subtype-3 agonists stimulate the growth of lung cancer cells and increase EGF receptor tyrosine phosphorylation.

Authors:  Terry W Moody; Veronica Sancho; Alessia di Florio; Bernardo Nuche-Berenguer; Samuel Mantey; Robert T Jensen
Journal:  Peptides       Date:  2011-06-25       Impact factor: 3.750

10.  Epigallocatechin gallate protects BEAS-2B cells from lipopolysaccharide-induced apoptosis through upregulation of gastrin-releasing peptide.

Authors:  Peethambaran Divya; Bijesh Puthusseri; Denny Joseph Kollareth Manual; Mohammed Azharuddin Savanur
Journal:  Mol Cell Biochem       Date:  2017-04-21       Impact factor: 3.396
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.