| Literature DB >> 16426578 |
Yuichi Tanaka1, Hiroyuki Marusawa, Hiroshi Seno, Yuko Matsumoto, Yoshihide Ueda, Yuzo Kodama, Yoko Endo, Junichi Yamauchi, Tomonori Matsumoto, Akifumi Takaori-Kondo, Iwao Ikai, Tsutomu Chiba.
Abstract
Apolipoprotein B mRNA-editing enzyme catalytic-polypeptide 3G (APOBEC3G) is a potent inhibitor of infection by a wide range of retroviruses. Although recent reports have suggested that human APOBEC3G exerts antiviral activity against hepatitis B virus, APOBEC3G expression is normally low in the human liver. To clarify the role of APOBEC3G in cellular defenses against hepatitis viruses, the regulation of the APOBEC3G expression was investigated in human hepatocytes. Endogenous transcripts of nine APOBEC family members were barely detectable in quiescent liver cells. However, APOBEC3G was significantly up-regulated in response to interferon-alpha (IFN-alpha) stimulation in HepG2, Huh-7, and primary human hepatocytes. IFN regulatory factor elements that are important for IFN-inducible promoter activity were identified 5' upstream from the human APOBEC3G gene. Our findings provided the first evidence showing that APOBEC3G is induced by IFN stimulation in human hepatocytes and thus could be involved in host defense mechanisms directed against hepatitis viruses.Entities:
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Year: 2006 PMID： 16426578 DOI： 10.1016/j.bbrc.2005.12.192
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575