OBJECTIVE: To determine the current standard ventilatory and cardiovascular management in potential organ donors. DESIGN: Prospective, multiple-center, observational survey. SETTING: A total of 15 intensive care units in 13 hospitals in Piedmont, Italy. PATIENTS: A total of 34 brain-dead patients enrolled in 6 months. MEASUREMENTS AND MAIN RESULTS: Demographics and reasons for lung transplant exclusion were recorded. Ventilatory and hemodynamic variables were compared before and after confirmation of brain death. A total of 23 potential donors were ineligible for lung donation based on pulmonary status and age. Of the 11 eligible lung donors, only two donated the lungs because five had Pao2/Fio2 ratios of <300 and four were ineligible for logistic problems. Tidal volume was 10 +/- 2 mL/kg, positive end-expiratory pressure was 3.3 +/- 2.7 cm H2O, Fio2 was 50% +/- 18% before brain death diagnosis, and no changes were made after brain death confirmation. In potential lung donors, apnea tests were performed with apneic oxygenation after disconnection from the ventilator in all cases; tracheal suction was performed with an open circuit in eight cases, and no recruitment maneuvers were performed. Crystalloid infusion was increased after diagnosis of brain death from 187 +/- 151 to 275 +/- 158 mL/hr (p < .05), and central venous pressure increased from 6 +/- 3 to 7 +/- 3 mm Hg (p < .05). Inotropic support was used in 24 donors (70%). CONCLUSIONS: Five of 11 potential lung donors (45%) had a Pao2/Fio2 ratio of <300, making them ineligible for lung donation. After the diagnosis of brain death, ventilatory management remained the same, no maneuvers for prevention of derecruitment of the lung were performed, and cardiovascular management was modified to optimize peripheral organ perfusion. These data represent the current standard of care for ventilatory management of potential organ donors and may be suboptimal in preserving lung function.
OBJECTIVE: To determine the current standard ventilatory and cardiovascular management in potential organ donors. DESIGN: Prospective, multiple-center, observational survey. SETTING: A total of 15 intensive care units in 13 hospitals in Piedmont, Italy. PATIENTS: A total of 34 brain-dead patients enrolled in 6 months. MEASUREMENTS AND MAIN RESULTS: Demographics and reasons for lung transplant exclusion were recorded. Ventilatory and hemodynamic variables were compared before and after confirmation of brain death. A total of 23 potential donors were ineligible for lung donation based on pulmonary status and age. Of the 11 eligible lung donors, only two donated the lungs because five had Pao2/Fio2 ratios of <300 and four were ineligible for logistic problems. Tidal volume was 10 +/- 2 mL/kg, positive end-expiratory pressure was 3.3 +/- 2.7 cm H2O, Fio2 was 50% +/- 18% before brain death diagnosis, and no changes were made after brain death confirmation. In potential lung donors, apnea tests were performed with apneic oxygenation after disconnection from the ventilator in all cases; tracheal suction was performed with an open circuit in eight cases, and no recruitment maneuvers were performed. Crystalloid infusion was increased after diagnosis of brain death from 187 +/- 151 to 275 +/- 158 mL/hr (p < .05), and central venous pressure increased from 6 +/- 3 to 7 +/- 3 mm Hg (p < .05). Inotropic support was used in 24 donors (70%). CONCLUSIONS: Five of 11 potential lung donors (45%) had a Pao2/Fio2 ratio of <300, making them ineligible for lung donation. After the diagnosis of brain death, ventilatory management remained the same, no maneuvers for prevention of derecruitment of the lung were performed, and cardiovascular management was modified to optimize peripheral organ perfusion. These data represent the current standard of care for ventilatory management of potential organ donors and may be suboptimal in preserving lung function.
Authors: Geert Meyfroidt; Jan Gunst; Ignacio Martin-Loeches; Martin Smith; Chiara Robba; Fabio Silvio Taccone; Giuseppe Citerio Journal: Intensive Care Med Date: 2019-02-11 Impact factor: 17.440
Authors: Rolando A Rebolledo; Anne C Van Erp; Petra J Ottens; Janneke Wiersema-Buist; Henri G D Leuvenink; Pamela Romanque Journal: PLoS One Date: 2015-10-05 Impact factor: 3.240
Authors: Rolando A Rebolledo; Bo Liu; Mohammed Z Akhtar; Petra J Ottens; Jian-Ning Zhang; Rutger J Ploeg; Henri G D Leuvenink Journal: Biomed Res Int Date: 2015-05-19 Impact factor: 3.411
Authors: Rolando Rebolledo; Bo Liu; Mohammed Z Akhtar; Petra J Ottens; Jian-ning Zhang; Rutger J Ploeg; Henri G D Leuvenink Journal: J Transl Med Date: 2014-05-02 Impact factor: 5.531
Authors: Anne C van Erp; Haiyun Qi; Nichlas R Jespersen; Marie V Hjortbak; Petra J Ottens; Janneke Wiersema-Buist; Rikke Nørregaard; Michael Pedersen; Christoffer Laustsen; Henri G D Leuvenink; Bente Jespersen Journal: Am J Transplant Date: 2020-06-15 Impact factor: 8.086