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Literature DB >> 1642464

Parkinsonism-inducing neurotoxin MPP+: uptake and toxicity in nonneuronal COS cells expressing dopamine transporter cDNA.

Abstract

Expression of a cloned dopamine transporter complementary DNA in COS cells allows these primate kidney cells to accumulate the parkinsonism-inducing neurotoxin metabolite MPP+ (1-methyl-4-phenylpyridinium) avidly, and MPP+ toxicity results. By documenting that the dopamine transporter can confer MPP+ sensitivity to nonneural cells, these results highlight the key role that this transporter could play in mechanisms underlying parkinsonism.

Entities: Chemical Disease Gene Species

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Year: 1992 PMID： 1642464 DOI： 10.1002/ana.410320120

Source DB: PubMed Journal: Ann Neurol ISSN： 0364-5134 Impact factor: 10.422

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Cited

12 in total

1. The dopamine transporter: comparative ultrastructure of dopaminergic axons in limbic and motor compartments of the nucleus accumbens.

Authors: M J Nirenberg; J Chan; A Pohorille; R A Vaughan; G R Uhl; M J Kuhar; V M Pickel
Journal: J Neurosci Date: 1997-09-15 Impact factor: 6.167

2. VMAT2 knockout mice: heterozygotes display reduced amphetamine-conditioned reward, enhanced amphetamine locomotion, and enhanced MPTP toxicity.

Authors: N Takahashi; L L Miner; I Sora; H Ujike; R S Revay; V Kostic; V Jackson-Lewis; S Przedborski; G R Uhl
Journal: Proc Natl Acad Sci U S A Date: 1997-09-02 Impact factor: 11.205

3. 1-Methylpyridinium-4-(4-phenylmethanethiosulfonate) iodide, MTS-MPP+, a novel scanning cysteine accessibility method (SCAM) reagent for monoamine transporter studies.

Authors: Alejandra Gallardo-Godoy; Melissa I Torres-Altoro; Kellie J White; Eric L Barker; David E Nichols
Journal: Bioorg Med Chem Date: 2006-09-29 Impact factor: 3.641

4. Recovery of hypothalamic tuberoinfundibular dopamine neurons from acute toxicant exposure is dependent upon protein synthesis and associated with an increase in parkin and ubiquitin carboxy-terminal hydrolase-L1 expression.

Authors: Matthew Benskey; Bahareh Behrouz; Johan Sunryd; Samuel S Pappas; Seung-Hoon Baek; Marianne Huebner; Keith J Lookingland; John L Goudreau
Journal: Neurotoxicology Date: 2012-02-09 Impact factor: 4.294

Review 5. Biology of membrane transport proteins.

Authors: W Sadée; V Drübbisch; G L Amidon
Journal: Pharm Res Date: 1995-12 Impact factor: 4.200

6. Increased expression of the dopamine transporter leads to loss of dopamine neurons, oxidative stress and l-DOPA reversible motor deficits.

Authors: S T Masoud; L M Vecchio; Y Bergeron; M M Hossain; L T Nguyen; M K Bermejo; B Kile; T D Sotnikova; W B Siesser; R R Gainetdinov; R M Wightman; M G Caron; J R Richardson; G W Miller; A J Ramsey; M Cyr; A Salahpour
Journal: Neurobiol Dis Date: 2014-10-30 Impact factor: 5.996

Parkinsonism-inducing neurotoxin MPP+: uptake and toxicity in nonneuronal COS cells expressing dopamine transporter cDNA.

1. The dopamine transporter: comparative ultrastructure of dopaminergic axons in limbic and motor compartments of the nucleus accumbens.

2. VMAT2 knockout mice: heterozygotes display reduced amphetamine-conditioned reward, enhanced amphetamine locomotion, and enhanced MPTP toxicity.

3. 1-Methylpyridinium-4-(4-phenylmethanethiosulfonate) iodide, MTS-MPP+, a novel scanning cysteine accessibility method (SCAM) reagent for monoamine transporter studies.

4. Recovery of hypothalamic tuberoinfundibular dopamine neurons from acute toxicant exposure is dependent upon protein synthesis and associated with an increase in parkin and ubiquitin carboxy-terminal hydrolase-L1 expression.

Review 5. Biology of membrane transport proteins.

6. Increased expression of the dopamine transporter leads to loss of dopamine neurons, oxidative stress and l-DOPA reversible motor deficits.

7. mu opiate receptor: cDNA cloning and expression.

8. Sex differences in striatal dopaminergic function within heterozygous mutant dopamine transporter knock-out mice.

9. Parkin disrupts the alpha-synuclein/dopamine transporter interaction: consequences toward dopamine-induced toxicity.

10. A Physical Interaction between the Dopamine Transporter and DJ-1 Facilitates Increased Dopamine Reuptake.