AIM: To describe the appearance of the non-exudative forms of age related macular degeneration (AMD) as imaged by ultrahigh resolution optical coherence tomography (UHR-OCT). METHODS: A UHR-OCT ophthalmic imaging system, which utilises a femtosecond laser light source capable of approximately 3 mum axial resolution, was employed to obtain retinal cross sectional images of patients with non-exudative AMD. Observational studies of the resulting retinal images were performed. RESULTS: 52 eyes of 42 patients with the clinical diagnosis of non-exudative AMD were imaged using the UHR-OCT system. 47 of the 52 (90%) eyes had the clinical diagnosis of drusen and/or retinal pigment epithelial (RPE) changes. In these patients, three patterns of drusen were apparent on UHR-OCT: (1) distinct RPE excrescences, (2) a saw toothed pattern of the RPE, and (3) nodular drusen. On UHR-OCT, three eyes (6%) with a clinical diagnosis of non-exudative AMD had evidence of fluid under the retina or RPE. Two of these three patients had findings suspicious for subclinical choroidal neovascularisation on UHR-OCT. CONCLUSION: With the increased resolution of UHR-OCT compared to standard OCT, the involvement of the outer retinal layers are more clearly defined. UHR-OCT may allow for the detection of early exudative changes not visible clinically or by angiography.
AIM: To describe the appearance of the non-exudative forms of age related macular degeneration (AMD) as imaged by ultrahigh resolution optical coherence tomography (UHR-OCT). METHODS: A UHR-OCT ophthalmic imaging system, which utilises a femtosecond laser light source capable of approximately 3 mum axial resolution, was employed to obtain retinal cross sectional images of patients with non-exudative AMD. Observational studies of the resulting retinal images were performed. RESULTS: 52 eyes of 42 patients with the clinical diagnosis of non-exudative AMD were imaged using the UHR-OCT system. 47 of the 52 (90%) eyes had the clinical diagnosis of drusen and/or retinal pigment epithelial (RPE) changes. In these patients, three patterns of drusen were apparent on UHR-OCT: (1) distinct RPE excrescences, (2) a saw toothed pattern of the RPE, and (3) nodular drusen. On UHR-OCT, three eyes (6%) with a clinical diagnosis of non-exudative AMD had evidence of fluid under the retina or RPE. Two of these three patients had findings suspicious for subclinical choroidal neovascularisation on UHR-OCT. CONCLUSION: With the increased resolution of UHR-OCT compared to standard OCT, the involvement of the outer retinal layers are more clearly defined. UHR-OCT may allow for the detection of early exudative changes not visible clinically or by angiography.
Authors: Elisabeth M Anger; Angelika Unterhuber; Boris Hermann; Harald Sattmann; Christian Schubert; James E Morgan; Alan Cowey; Peter K Ahnelt; Wolfgang Drexler Journal: Exp Eye Res Date: 2004-06 Impact factor: 3.467
Authors: D Huang; E A Swanson; C P Lin; J S Schuman; W G Stinson; W Chang; M R Hee; T Flotte; K Gregory; C A Puliafito Journal: Science Date: 1991-11-22 Impact factor: 47.728
Authors: Keven J Blinder; Shannon Bradley; Neil M Bressler; Susan B Bressler; Guy Donati; Yong Hao; Colin Ma; Ugo Menchini; Joan Miller; Michael J Potter; Constantin Pournaras; Al Reaves; Philip J Rosenfeld; H Andrew Strong; Michael Stur; Xiang Yao Su; Gianni Virgili Journal: Am J Ophthalmol Date: 2003-09 Impact factor: 5.258
Authors: Mark E Clark; Gerald McGwin; David Neely; Richard Feist; John O Mason; Martin Thomley; Milton F White; Bunyamin Ozaydin; Christopher A Girkin; Cynthia Owsley Journal: Br J Ophthalmol Date: 2011-02-02 Impact factor: 4.638
Authors: Joseph Ho; Andre J Witkin; Jonathan Liu; Yueli Chen; James G Fujimoto; Joel S Schuman; Jay S Duker Journal: Ophthalmology Date: 2010-11-20 Impact factor: 12.079
Authors: Chandrakumar Balaratnasingam; Jeffrey D Messinger; Kenneth R Sloan; Lawrence A Yannuzzi; K Bailey Freund; Christine A Curcio Journal: Ophthalmology Date: 2017-01-30 Impact factor: 12.079
Authors: Nieraj Jain; Sina Farsiu; Aziz A Khanifar; Srilaxmi Bearelly; R Theodore Smith; Joseph A Izatt; Cynthia A Toth Journal: Invest Ophthalmol Vis Sci Date: 2010-04-14 Impact factor: 4.799
Authors: Giovanni Gregori; Fenghua Wang; Philip J Rosenfeld; Zohar Yehoshua; Ninel Z Gregori; Brandon J Lujan; Carmen A Puliafito; William J Feuer Journal: Ophthalmology Date: 2011-03-09 Impact factor: 12.079
Authors: I Gorczynska; V J Srinivasan; L N Vuong; R W S Chen; J J Liu; E Reichel; M Wojtkowski; J S Schuman; J S Duker; J G Fujimoto Journal: Br J Ophthalmol Date: 2008-07-28 Impact factor: 4.638
Authors: Jessica N Leuschen; Stefanie G Schuman; Katrina P Winter; Michelle N McCall; Wai T Wong; Emily Y Chew; Thomas Hwang; Sunil Srivastava; Neeru Sarin; Traci Clemons; Molly Harrington; Cynthia A Toth Journal: Ophthalmology Date: 2012-09-08 Impact factor: 12.079
Authors: Joseph G Christenbury; Francisco A Folgar; Rachelle V O'Connell; Stephanie J Chiu; Sina Farsiu; Cynthia A Toth Journal: Ophthalmology Date: 2013-01-23 Impact factor: 12.079