| Literature DB >> 16423613 |
Eric A Huang1, Brian J Feldman, I David Schwartz, David H Geller, Stephen M Rosenthal, Stephen E Gitelman.
Abstract
We report the successful use of oral urea in the management of children with chronic syndrome of inappropriate antidiuretic hormone secretion (SIAD). We performed a retrospective review of four children with chronic SIAD. After initial attempts at management with fluid restriction, each was started on a 30% to 50% oral urea solution, and the dose was titrated until normal serum sodium was achieved. Fluid intake was liberalized after serum sodium normalization. All four children normalized their serum sodium. No side effects or toxicities were experienced. Oral urea is a safe, effective treatment for chronic SIAD in children.Entities:
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Year: 2006 PMID： 16423613 DOI： 10.1016/j.jpeds.2005.08.031
Source DB: PubMed Journal: J Pediatr ISSN： 0022-3476 Impact factor: 4.406