OBJECTIVE: Recent work has focussed on schizophrenia as a 'deficit' state but little attention has been paid to defining illness plasticity in terms of symptomatic remission. METHOD: A qualitative review of a recently proposed concept of remission [N.C. Andreasen, W.T. Carpenter Jr, J.M. Kane, R.A. Lasser, S.R. Marder, D.R. Weinberger (2005) Am J Psychiatry 162: 441] is presented. RESULTS: The proposed definition of remission is conceptually viable, and can be easily implemented in clinical trials and clinical practice. Its increasing acceptance may reset expectations of treatment to a higher level, improve documentation of clinical status and facilitate dialogue on treatment expectations. The availability of validated outcome measures based on remission will enhance the conduct and reporting of clinical investigations, and could facilitate the design and interpretation of new studies on cognition and functional outcomes. While useful as a concept, it is important to consider that remission is distinct from recovery. CONCLUSION: The introduction of standardized remission criteria may offer significant opportunities for clinical practice, health services research and clinical trials.
OBJECTIVE: Recent work has focussed on schizophrenia as a 'deficit' state but little attention has been paid to defining illness plasticity in terms of symptomatic remission. METHOD: A qualitative review of a recently proposed concept of remission [N.C. Andreasen, W.T. Carpenter Jr, J.M. Kane, R.A. Lasser, S.R. Marder, D.R. Weinberger (2005) Am J Psychiatry 162: 441] is presented. RESULTS: The proposed definition of remission is conceptually viable, and can be easily implemented in clinical trials and clinical practice. Its increasing acceptance may reset expectations of treatment to a higher level, improve documentation of clinical status and facilitate dialogue on treatment expectations. The availability of validated outcome measures based on remission will enhance the conduct and reporting of clinical investigations, and could facilitate the design and interpretation of new studies on cognition and functional outcomes. While useful as a concept, it is important to consider that remission is distinct from recovery. CONCLUSION: The introduction of standardized remission criteria may offer significant opportunities for clinical practice, health services research and clinical trials.
Authors: O Puig; R Penadés; I Baeza; V Sánchez-Gistau; E De la Serna; L Fonrodona; S Andrés-Perpiñá; M Bernardo; J Castro-Fornieles Journal: Eur Child Adolesc Psychiatry Date: 2012-02-22 Impact factor: 4.785
Authors: Maarten Bak; Philippe Delespaul; Lydia Krabbendam; Karola Huistra; Wil Walraven; Jim van Os Journal: Int J Methods Psychiatr Res Date: 2009 Impact factor: 4.035
Authors: Christopher Fear; David Yeomans; Bryan Moore; Mark Taylor; Keith Ford; Alan Currie; Joanne Hynes; Gary Sullivan; Richard Whale; Tom Burns Journal: Ment Health Fam Med Date: 2009-06
Authors: Marjan Drukker; Maarten Bak; Joost à Campo; Ger Driessen; Jim Van Os; Philippe Delespaul Journal: Soc Psychiatry Psychiatr Epidemiol Date: 2009-07-02 Impact factor: 4.328