Comparison of anxiety-like behavior in adolescent and adult Sprague-Dawley rats.

The conditions under which age differences in anxiety are observed in rodents are unclear. These studies explored the influence of test condition on anxiety-like behavior in adolescent and adult rats using the light-dark box. Behavior was assessed under different illumination levels (30 or 60 lux) and after brief stress (restraint or bright light). Anxiety-like behavior did not differ in the 30-lux test but was increased in adolescents in the 60-lux test. Restraint increased anxiety-like behavior in adolescents, resulting in elevated anxiety-like behavior relative to adults. Bright light decreased anxiety-like behavior, possibly because of negative contrast or novelty-induced anxiolysis. These studies demonstrate that adolescents display increased anxiety-like behavior when test conditions are more aversive and following exposure to stress. Copyright (c) 2006 APA, all rights reserved.