Literature DB >> 16418686

Therapeutic drug monitoring of antithyroid drugs in pregnancy: the knowledge gaps.

Gideon Koren1, Offie Soldin.   

Abstract

Despite being a common condition in pregnancy, and despite propylthiouracil (PTU) being perceived as safer than methimazole, there are virtually no epidemiological controlled studies on malformation rate an neurobehavioral outcomes with the former. This knowledge gap must be filled to ensure fetal safety.

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Year:  2006        PMID： 16418686      PMCID： PMC3635531          DOI： 10.1097/01.ftd.0000192135.54477.d9

Source DB:  PubMed          Journal:  Ther Drug Monit        ISSN： 0163-4356            Impact factor:   3.681


  13 in total

1.  Adverse effects of prenatal methimazole exposure.

Authors:  E Di Gianantonio; C Schaefer; P P Mastroiacovo; M P Cournot; F Benedicenti; M Reuvers; B Occupati; E Robert; B Bellemin; A Addis; J Arnon; M Clementi
Journal:  Teratology       Date:  2001-11

2.  How women perceive teratogenic risk and what they do about it.

Authors:  G Koren; M Bologa; A Pastuszak
Journal:  Ann N Y Acad Sci       Date:  1993-03-15       Impact factor: 5.691

3.  Methimazole and propylthiouracil equally cross the perfused human term placental lobule.

Authors:  R H Mortimer; G R Cannell; R S Addison; L P Johnson; M S Roberts; I Bernus
Journal:  J Clin Endocrinol Metab       Date:  1997-09       Impact factor: 5.958

4.  Triphasic changes in thyroid function in a patient with primary hypothyroidism in the course of pregnancy and the early post-partum period.

Authors:  S Ohguni; K Notsu; Y Kato
Journal:  Endocr J       Date:  1997-08       Impact factor: 2.349

5.  Propylthiouracil (PTU)-induced hypothyroidism in the developing rat impairs synaptic transmission and plasticity in the dentate gyrus of the adult hippocampus.

Authors:  M E Gilbert; C Paczkowski
Journal:  Brain Res Dev Brain Res       Date:  2003-10-10

6.  Treatment of hyperthyroidism in pregnancy with propylthiouracil and methimazole.

Authors:  Q Mujtaba; G N Burrow
Journal:  Obstet Gynecol       Date:  1975-09       Impact factor: 7.661

7.  Effects of propylthiouracil and methimazole on fetal thyroid status in mothers with Graves' hyperthyroidism.

Authors:  N Momotani; J Y Noh; N Ishikawa; K Ito
Journal:  J Clin Endocrinol Metab       Date:  1997-11       Impact factor: 5.958

8.  Perception of teratogenic risk by pregnant women exposed to drugs and chemicals during the first trimester.

Authors:  G Koren; M Bologa; D Long; Y Feldman; N H Shear
Journal:  Am J Obstet Gynecol       Date:  1989-05       Impact factor: 8.661

9.  Pharmacology of propylthiouracil (PTU) in pregnant hyperthyroid women: correlation of maternal PTU concentrations with cord serum thyroid function tests.

Authors:  D F Gardner; D P Cruikshank; P M Hays; D S Cooper
Journal:  J Clin Endocrinol Metab       Date:  1986-01       Impact factor: 5.958

10.  Thyroid function and intellectual development of children of mothers taking methimazole during pregnancy.

Authors:  F Azizi; M E Khamseh; M Bahreynian; M Hedayati
Journal:  J Endocrinol Invest       Date:  2002 Jul-Aug       Impact factor: 4.256
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  3 in total

1.  Propylthiouracil is teratogenic in murine embryos.

Authors:  Valeria C Benavides; Murali K Mallela; Carmen J Booth; Christopher C Wendler; Scott A Rivkees
Journal:  PLoS One       Date:  2012-04-18       Impact factor: 3.240

2.  Embryonic exposure to propylthiouracil disrupts left-right patterning in Xenopus embryos.

Authors:  Nicole R van Veenendaal; Bärbel Ulmer; Marko T Boskovski; Xiefan Fang; Mustafa K Khokha; Christopher C Wendler; Martin Blum; Scott A Rivkees
Journal:  FASEB J       Date:  2012-11-12       Impact factor: 5.191

3.  Pregnancy outcome, thyroid dysfunction and fetal goitre after in utero exposure to propylthiouracil: a controlled cohort study.

Authors:  Hila Rosenfeld; Asher Ornoy; Svetlana Shechtman; Orna Diav-Citrin
Journal:  Br J Clin Pharmacol       Date:  2009-10       Impact factor: 4.335
  3 in total

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