Literature DB >> 16417212

UVA-irradiated pheomelanin alters the structure of catalase and decreases its activity in human skin.

John M Wood1, Karin U Schallreuter.   

Abstract

More than 40 years ago Aronoff showed that catalase structure and activity is seriously affected by photo-oxidation of its own substrate, hydrogen peroxide, owing to cleavage of its porphyrin active site. Here we support the results of Maresca et al. and expand on them by using structural modeling of native catalase and its photo-oxidation product, where both methionine and tryptophan residues are oxidized, yielding a deactivated enzyme.

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Year:  2006        PMID： 16417212     DOI： 10.1038/sj.jid.5700051

Source DB:  PubMed          Journal:  J Invest Dermatol        ISSN： 0022-202X            Impact factor:   8.551


  3 in total

1.  Catalase -262C>T polymorphisms in Hungarian vitiligo patients and in controls: further acatalasemia mutations in Hungary.

Authors:  Zsuzsanna Kósa; Zsolt Fejes; Teréz Nagy; Melinda Csordás; Enikő Simics; Eva Remenyik; László Góth
Journal:  Mol Biol Rep       Date:  2011-09-24       Impact factor: 2.316

Review 2.  Mechanisms of oxidant generation by catalase.

Authors:  Diane E Heck; Michael Shakarjian; Hong Duck Kim; Jeffrey D Laskin; Anna M Vetrano
Journal:  Ann N Y Acad Sci       Date:  2010-08       Impact factor: 5.691

3.  Mutations in the selenocysteine insertion sequence-binding protein 2 gene lead to a multisystem selenoprotein deficiency disorder in humans.

Authors:  Erik Schoenmakers; Maura Agostini; Catherine Mitchell; Nadia Schoenmakers; Laura Papp; Odelia Rajanayagam; Raja Padidela; Lourdes Ceron-Gutierrez; Rainer Doffinger; Claudia Prevosto; Jian'an Luan; Sergio Montano; Jun Lu; Mireille Castanet; Nick Clemons; Matthijs Groeneveld; Perrine Castets; Mahsa Karbaschi; Sri Aitken; Adrian Dixon; Jane Williams; Irene Campi; Margaret Blount; Hannah Burton; Francesco Muntoni; Dominic O'Donovan; Andrew Dean; Anne Warren; Charlotte Brierley; David Baguley; Pascale Guicheney; Rebecca Fitzgerald; Alasdair Coles; Hill Gaston; Pamela Todd; Arne Holmgren; Kum Kum Khanna; Marcus Cooke; Robert Semple; David Halsall; Nicholas Wareham; John Schwabe; Lucia Grasso; Paolo Beck-Peccoz; Arthur Ogunko; Mehul Dattani; Mark Gurnell; Krishna Chatterjee
Journal:  J Clin Invest       Date:  2010-11-15       Impact factor: 14.808
  3 in total

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