Literature DB >> 16416396

The role of excitotoxicity in neurodegeneration.

Elzbieta Salińska1, Wojciech Danysz, Jerzy W Łazarewicz.   

Abstract

A body of evidence suggests that the mechanisms of excitotoxic neuronal damage evoked by excessive or prolonged activation of the excitatory amino acid receptors may be involved in pathogenesis of brain damage in acute insults and in chronic neurodegenerative diseases. In this review we briefly discuss several selected mechanisms of the excitotoxicity, focusing attention on the role of ionotropic glutamate receptors, calcium transients and calcium-mediated cell injury. In the second part of this paper we provide information on elements of excitotoxicity in brain diseases.

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Year:  2005        PMID： 16416396

Source DB:  PubMed          Journal:  Folia Neuropathol        ISSN： 1509-572X            Impact factor:   2.038


  25 in total

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Authors:  Matthew K Brittain; Tatiana Brustovetsky; Joel M Brittain; Rajesh Khanna; Theodore R Cummins; Nickolay Brustovetsky
Journal:  Neuropharmacology       Date:  2012-07-20       Impact factor: 5.250

2.  Notch signaling in response to excitotoxicity induces neurodegeneration via erroneous cell cycle reentry.

Authors:  S Marathe; S Liu; E Brai; M Kaczarowski; L Alberi
Journal:  Cell Death Differ       Date:  2015-03-27       Impact factor: 15.828

3.  Delayed calcium dysregulation in neurons requires both the NMDA receptor and the reverse Na+/Ca2+ exchanger.

Authors:  Matthew K Brittain; Tatiana Brustovetsky; Patrick L Sheets; Joel M Brittain; Rajesh Khanna; Theodore R Cummins; Nickolay Brustovetsky
Journal:  Neurobiol Dis       Date:  2012-01-10       Impact factor: 5.996

4.  Pirfenidone Attenuates Microglial Reactivity and Reduces Inducible Nitric Oxide Synthase mRNA Expression After Kainic Acid-Mediated Excitotoxicity in Pubescent Rat Hippocampus.

Authors:  Rubén Darío Castro-Torres; Verónica Chaparro-Huerta; Mario Eduardo Flores-Soto; Luis Jave-Suárez; Antoni Camins; Juan Armendáriz-Borunda; Carlos Beas-Zárate; Salvador Mena-Munguía
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5.  Bark Constituents from Mushroom-detoxified Rhus verniciflua Suppress Kainic Acid-induced Neuronal Cell Death in Mouse Hippocampus.

Authors:  Jong-Seon Byun; Yoon Hee Han; Sung-Jun Hong; Sung-Mi Hwang; Yong-Soo Kwon; Hee Jae Lee; Sung-Soo Kim; Myong-Jo Kim; Wanjoo Chun
Journal:  Korean J Physiol Pharmacol       Date:  2010-10-31       Impact factor: 2.016

6.  The Neuroprotective Peptide Poly-Arginine-12 (R12) Reduces Cell Surface Levels of NMDA NR2B Receptor Subunit in Cortical Neurons; Investigation into the Involvement of Endocytic Mechanisms.

Authors:  Gabriella MacDougall; Ryan S Anderton; Adam B Edwards; Neville W Knuckey; Bruno P Meloni
Journal:  J Mol Neurosci       Date:  2016-11-20       Impact factor: 3.444

7.  Collapsin response mediator protein 2 (CRMP2) interacts with N-methyl-D-aspartate (NMDA) receptor and Na+/Ca2+ exchanger and regulates their functional activity.

Authors:  Tatiana Brustovetsky; Jessica J Pellman; Xiao-Fang Yang; Rajesh Khanna; Nickolay Brustovetsky
Journal:  J Biol Chem       Date:  2014-01-28       Impact factor: 5.157

8.  Neural protection by naturopathic compounds-an example of tetramethylpyrazine from retina to brain.

Authors:  Zhiqun Tan
Journal:  J Ocul Biol Dis Infor       Date:  2009-07-14

9.  Erratum: Neural protection by naturopathic compounds-an example of tetramethylpyrazine from retina to brain.

Authors:  Zhiqun Tan
Journal:  J Ocul Biol Dis Infor       Date:  2009-09-01

10.  Upregulation of alpha7 Nicotinic Receptors by Acetylcholinesterase C-Terminal Peptides.

Authors:  Cherie E Bond; Martina Zimmermann; Susan A Greenfield
Journal:  PLoS One       Date:  2009-03-16       Impact factor: 3.240
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